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dc.contributor.author
Dubocovich, Margarita L.
dc.contributor.author
Delagrange, Philippe
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Krause, Diana N.
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Sugden, David
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Cardinali, Daniel Pedro
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Olcese, James
dc.date.available
2023-03-17T14:33:43Z
dc.date.issued
2010-09
dc.identifier.citation
Dubocovich, Margarita L.; Delagrange, Philippe; Krause, Diana N.; Sugden, David; Cardinali, Daniel Pedro; et al.; International union of basic and clinical pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors; American Society for Pharmacology and Experimental Therapeutics; Pharmacological Reviews; 62; 3; 9-2010; 343-380
dc.identifier.issn
0031-6997
dc.identifier.uri
http://hdl.handle.net/11336/190895
dc.description.abstract
The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the concentration of melatonin follows a circadian rhythm, with high levels at night providing timing cues to target tissues endowed with melatonin receptors. Melatonin receptors receive and translate melatonin's message to influence daily and seasonal rhythms of physiology and behavior. The melatonin message is translated through activation of two G protein-coupled receptors, MT1 and MT2, that are potential therapeutic targets in disorders ranging from insomnia and circadian sleep disorders to depression, cardiovascular diseases, and cancer. This review summarizes the steps taken since melatonin's discovery by Aaron Lerner in 1958 to functionally characterize, clone, and localize receptors in mammalian tissues. The pharmacological and molecular properties of the receptors are described as well as current efforts to discover and develop ligands for treatment of a number of illnesses, including sleep disorders, depression, and cancer.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Pharmacology and Experimental Therapeutics
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MELATONINA
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NOMENCLATURA
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FARMACOLOGIA
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
International union of basic and clinical pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-12T15:43:11Z
dc.journal.volume
62
dc.journal.number
3
dc.journal.pagination
343-380
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Baltimore
dc.description.fil
Fil: Dubocovich, Margarita L.. Northwestern University; Estados Unidos. Jacobs School Of Medicine And Biomedical Sciences; Estados Unidos
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Fil: Delagrange, Philippe. Institut de Recherches Servier; Francia
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Fil: Krause, Diana N.. University of California; Estados Unidos
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Fil: Sugden, David. King's College London; Reino Unido
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Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
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Fil: Olcese, James. Florida State University; Estados Unidos
dc.journal.title
Pharmacological Reviews
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pharmrev.aspetjournals.org/content/62/3/343
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info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1124/pr.110.002832
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