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dc.contributor.author
Monti, Daniela
dc.contributor.author
Tampucci, Silvia
dc.contributor.author
Chetoni, Patrizia
dc.contributor.author
Burgalassi, Susi
dc.contributor.author
Saino, Veronica
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dc.contributor.author
Centini, Marisanna
dc.contributor.author
Staltari, Lucia
dc.contributor.author
Anselmi, Cecilia
dc.date.available
2023-03-17T10:26:12Z
dc.date.issued
2011-09
dc.identifier.citation
Monti, Daniela; Tampucci, Silvia; Chetoni, Patrizia; Burgalassi, Susi; Saino, Veronica; et al.; Permeation and distribution of ferulic acid and its α-cyclodextrin complex from different formulations in hairless rat skin; Springer; AAPS Pharmscitech; 12; 2; 9-2011; 514-520
dc.identifier.issn
1530-9932
dc.identifier.uri
http://hdl.handle.net/11336/190847
dc.description.abstract
Ferulic acid (FA) is a natural product that occurs in seeds of many plants where it is generally located in the bran. This compound is a multifunctional ingredient endowed with antioxidative, radical scavenging, sunscreening and antibacterial actions. The aim of this study was to analyse the ferulic acid cutaneous permeation and distribution, through and into the skin layers, from different cosmetic vehicles, an O/W emulsion (pH 6.0) and two gel-type formulations at different pH levels (6.0 and 7.4), containing FA alone or an inclusion complex with α-cyclodextrin (CD-FA). In vitro permeation studies were performed in vertical diffusion cells using hairless rat excised skin. At appropriate intervals of time, the amount of permeated sunscreen/radical scavenger was evaluated by high-performance liquid chromatography (HPLC). At the end of experiments, treated skin samples were sectioned with a cryomicrotome and the FA content of the individual slices was analysed by HPLC. FA-containing formulations, O/W emulsion, gels A and B, originated FA fluxes of 8.48±2.31, 8.38±0.89 and 5.72±0.50 μg/cm2 h, respectively, thus suggesting the pH influence on FA percutaneous permeation. The use of the inclusion complex, CD-FA, determined in all cases a decrease of FA transdermal permeation while no influence of pH was observed. Gel-type formulations containing FA ensured higher sunscreen storage in the superficial layers if compared with O/W emulsion. When FA was included in α-cyclodextrin, FA amount retained into skin layers decreased markedly.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FERULIC ACID
dc.subject
SKIN DISTRIBUTION
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SKIN PERMEATION
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SUNSCREEN/ANTIOXIDANT AGENTS
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Α-CYCLODEXTRIN COMPLEX
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Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Permeation and distribution of ferulic acid and its α-cyclodextrin complex from different formulations in hairless rat skin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-15T20:27:55Z
dc.journal.volume
12
dc.journal.number
2
dc.journal.pagination
514-520
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Monti, Daniela. Università degli Studi di Pisa; Italia
dc.description.fil
Fil: Tampucci, Silvia. Università degli Studi di Pisa; Italia
dc.description.fil
Fil: Chetoni, Patrizia. Università degli Studi di Pisa; Italia
dc.description.fil
Fil: Burgalassi, Susi. Università degli Studi di Pisa; Italia
dc.description.fil
Fil: Saino, Veronica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
dc.description.fil
Fil: Centini, Marisanna. Università degli Studi di Siena; Italia
dc.description.fil
Fil: Staltari, Lucia. Università degli Studi di Siena; Italia
dc.description.fil
Fil: Anselmi, Cecilia. Università degli Studi di Siena; Italia
dc.journal.title
AAPS Pharmscitech
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1208/s12249-011-9609-y
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1208/s12249-011-9609-y
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