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dc.contributor.author
Prestifilippo, Juan Pablo
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Medina, Vanina Araceli
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Mohn, Claudia Ester
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Rodriguez, P. A.
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Elverdin, Juan Carlos
dc.contributor.author
Fernández Solari, Jose Javier
dc.date.available
2015-09-02T15:48:14Z
dc.date.issued
2013-09
dc.identifier.citation
Prestifilippo, Juan Pablo; Medina, Vanina Araceli; Mohn, Claudia Ester; Rodriguez, P. A.; Elverdin, Juan Carlos; et al.; Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus; Pergamon-Elsevier Science Ltd; Archives of Oral Biology; 58; 9; 9-2013; 1251-1259
dc.identifier.issn
0003-9969
dc.identifier.uri
http://hdl.handle.net/11336/1906
dc.description.abstract
Objective: The aim of this study was to investigate the factors that could participate on salivary glands hypofunction during inflammation and the participation of endocannabinoids in hyposalivation induced by the presence of inflammogens in the submandibular gland (SMG) or in the brain. Design: Salivary secretion was assessed in the presence of inflammogens and/or the cannabinoid receptor antagonist AM251 in the SMG or in the brain of rats. At the end of the experiments, some systemic and glandular inflammatory markers were measured and histopathological analysis was performed. Results: The inhibitory effect observed 1 h after lipopolysaccharide (LPS, 50 μg/50 μl) injection into the SMG (ig) was completely prevented by the injection of AM251 (5 μg/50 μl) by the same route (P < 0.05). The LPS (ig)-induced increase in PGE2 content was not altered by AM251 (ig), while the glandular production of TNFa induced by the endotoxin (P < 0.001) was partially blocked by it. Also, LPS injection produced no significant changes in the wet weight of the SMG neither damage to lipid membranes of its cells, nor significant microscopic changes in them, after hispopathological analysis, compared to controls. Finally, TNFα (100 ng/5 μl) injected intracerebro-ventricularly (icv) inhibited methacholine-induced salivary secretion evaluated 30 min after (P < 0.01), but the previous injection of AM251 (500 ng/5 μl, icv) prevented completely that effect. Conclusion: We conclude that endocannabinoids mediate the hyposialia induced by inflammogens in the SMG and in the brain. The hypofunction would be due to changes on signalling pathway produced by inflammatory compounds since anatomical changes were not observed. © 2013 Elsevier Ltd. All rights reserved.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ENDOCANNABINOID SYSTEM
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LIPOPOLYSACCHARIDE
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PROSTAGLANDIN E2
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SALIVA
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TUMOUR NECROSIS FACTOR ALPHA
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Odontología, Medicina y Cirugía Oral
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
58
dc.journal.number
9
dc.journal.pagination
1251-1259
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Prestifilippo, Juan Pablo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina
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Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
dc.description.fil
Fil: Mohn, Claudia Ester. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Rodriguez, P. A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - La Plata. Unidad de Administración Territorial; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
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Fil: Elverdin, Juan Carlos. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
dc.description.fil
Fil: Fernández Solari, Jose Javier. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
Archives of Oral Biology
dc.relation.isreferencedin
info:eu-repo/semantics/reference/url/info:eu-repo/semantics/reference es info:eu-repo/semantics/reference/pmid/23684250
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0003996913001179
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.odon.uba.ar/uacad/fisiologia/docs/nuevos/arch_oral_biol_2013.pdf
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.archoralbio.2013.04.003
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