Artículo
Regulatory and effector T-cells are differentially modulated by Dexamethasone
Pandolfi, Julieta Belen
; Baz, Placida
; Fernandez, Pablo Mariano
; Discianni Lupi, Ailen; Payaslián, Florencia; Billordo, Luis Ariel
; Fainboim, Leonardo
; Arruvito, Maria Lourdes
Fecha de publicación:
12/2013
Editorial:
Elsevier
Revista:
Clinical Immunology
ISSN:
1521-6616
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
It is assumed that the ratio between effector T cells (Teff) and regulatory T cells (Tregs) controls the immune reactivity within the T-cell compartment. The purpose of this study was to investigate if Dexamethasone (Dex) affects Teff and Tregs subsets. Dex induced on Tregs a dose and time-dependent apoptosis which resulted in a relative increase of Teff. After TCR activation, Dex induced a strong proliferative inhibition of Teff, but a weaker proliferative inhibition on Tregs. These effects were modulated by IL-2, which not only restored the proliferative response, but also prevented Dex-induced apoptosis. The highest dose of IL-2 prevented apoptosis on all FOXP3 + CD4+ T cells. Meanwhile, the lowest dose only rescued activated Tregs (aTregs), probably related to their CD25 higher expression. Because Dex did not affect the suppressor capacity of aTregs either, our results support the notion that under Dex treatment, the regulatory T-cell compartmentmaintains its homeostasis.
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Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Pandolfi, Julieta Belen; Baz, Placida; Fernandez, Pablo Mariano; Discianni Lupi, Ailen; Payaslián, Florencia; et al.; Regulatory and effector T-cells are differentially modulated by Dexamethasone; Elsevier; Clinical Immunology; 149; 3B; 12-2013; 400-410
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