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dc.contributor.author
Delgado, Fernando Oscar
dc.contributor.author
Estrada Chávez, C.
dc.contributor.author
Romano, Maria Isabel
dc.contributor.author
Paolicchi, F.
dc.contributor.author
Blanco Viera, F.
dc.contributor.author
Capellino, F.
dc.contributor.author
Chavez Gris, G.
dc.contributor.author
Pereira Suárez, A. L.
dc.date.available
2023-03-09T14:37:13Z
dc.date.issued
2010-09
dc.identifier.citation
Delgado, Fernando Oscar; Estrada Chávez, C.; Romano, Maria Isabel; Paolicchi, F.; Blanco Viera, F.; et al.; Expression of NRAMP1 and iNOS in Mycobacterium avium subsp. paratuberculosis naturally infected cattle; Elsevier; Comparative Immunology, Microbiology and Infectious Diseases; 33; 5; 9-2010; 389-400
dc.identifier.issn
0147-9571
dc.identifier.uri
http://hdl.handle.net/11336/190066
dc.description.abstract
Paratuberculosis (PTB) is a chronic disease caused by M. avium subsp. paratuberculosis (MAP) that affects several animal species, and some studies have suggested that there may be a relationship between Crohn's disease and PTB. Significant aspects of PTB pathogenesis are not yet completely understood, such as the role of macrophages. Natural resistance-associated macrophage protein 1 (NRAMP1) and the inducible nitric oxide synthase (iNOS) molecules have shown nonspecific effects against several intracellular pathogens residing within macrophages. However, these molecules have been scarcely studied during natural infection with MAP. In this work, changes in NRAMP1 and iNOS expression were surveyed by immunohistochemistry in tissue samples from MAP-infected cattle and healthy controls. Our findings show strong specific immunolabeling against both NRAMP1 and iNOS molecules, throughout granulomatous PTB-compatible lesions in ileum and ileocaecal lymph nodes from paratuberculous cattle compared with uninfected controls, suggesting a relationship between the expression of these molecules and the pathogenesis of PTB disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CATTLE
dc.subject
JOHNE'S DISEASE
dc.subject
MAP
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NRAMP1
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PARATUBERCULOSIS
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SLC11A1 AND INOS
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Expression of NRAMP1 and iNOS in Mycobacterium avium subsp. paratuberculosis naturally infected cattle
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-08T13:01:26Z
dc.journal.volume
33
dc.journal.number
5
dc.journal.pagination
389-400
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina
dc.description.fil
Fil: Estrada Chávez, C.. Universidad Autonoma del Estado de Hidalgo; México. Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco; México
dc.description.fil
Fil: Romano, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria; Argentina
dc.description.fil
Fil: Paolicchi, F.. Instituto Nacional de Tecnología Agropecuaria; Argentina
dc.description.fil
Fil: Blanco Viera, F.. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina
dc.description.fil
Fil: Capellino, F.. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina
dc.description.fil
Fil: Chavez Gris, G.. Universidad Nacional Autónoma de México; México
dc.description.fil
Fil: Pereira Suárez, A. L.. Universidad de Guadalajara; México. Universidad Autonoma del Estado de Hidalgo; México
dc.journal.title
Comparative Immunology, Microbiology and Infectious Diseases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0147957109000174
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.cimid.2009.03.001
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