Mostrar el registro sencillo del ítem
dc.contributor.author
Cano Barquilla, Pilar
dc.contributor.author
Cardinali, Daniel Pedro
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Jimenez Ortega, Vanesa
dc.contributor.author
Scacchi Bernasconi, Pablo Antonio
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Esquifino, Ana Isabel
dc.date.available
2023-03-07T11:17:16Z
dc.date.issued
2010-06
dc.identifier.citation
Cano Barquilla, Pilar; Cardinali, Daniel Pedro; Jimenez Ortega, Vanesa; Scacchi Bernasconi, Pablo Antonio; Esquifino, Ana Isabel; Effect of a high-fat diet on 24-hour pattern in expression of prolactin and redox pathway enzymes in the rat adenohypophysis; Bentham Science Publishers; The Open Obesity Journal; 2; 6-2010; 1-9
dc.identifier.issn
1876-8237
dc.identifier.uri
http://hdl.handle.net/11336/189755
dc.description.abstract
The effect of a high-fat diet (35% fat) on 24-h changes in expression of prolactin and redox pathway enzyme genes was examined in the anterior pituitary of male rats. When body weight of high-fat fed rats attained values about 20- 25 % higher than controls (after 66 days of treatment) animals were sacrificed at 6 different time intervals throughout a 24-h cycle. Anterior pituitary mRNA levels were measured by real-time PCR analysis. In control rats expression of the prolactin gene peaked in anterior pituitary at early scotophase, 3 h in advance to the peak in plasma prolactin levels. In high-fat fed rats this correlation was lost. A disruption of 24-h rhythmicity of pituitary gene expression of heme oxygenase (HO)-2, Cu/Zn- superoxide dismutases (SOD), Mn-SOD, catalase, glutathione peroxidase (GPx) and glutathione reductase (GR) was apparent in high-fat fed rats. Anterior pituitary mRNA levels for nitric oxide synthase (NOS)-2 and HO-2, Cu/Zn- and Mn- SOD and catalase augmented in high-fat fed rats, whereas those of GPx and GR decreased. The results indicate a disrupted coordination between prolactin gene expression and prolactin release in highfat fed rats that comes along with a disturbed expression of redox enzyme genes in the anterior pituitary.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DIETA RICA EN GRASAS
dc.subject
RITMO CIRCADIANO
dc.subject
EXPRESION GÉNICA
dc.subject
PROLACTINA
dc.subject
ÓXIDO NÍTRICO SINTASA
dc.subject
HEMO-OXIGENASA
dc.subject
CATALASA
dc.subject
SUPERÓXIDO DISMUTASA
dc.subject.classification
Neurociencias
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Básica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Effect of a high-fat diet on 24-hour pattern in expression of prolactin and redox pathway enzymes in the rat adenohypophysis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-02T15:10:42Z
dc.journal.volume
2
dc.journal.pagination
1-9
dc.journal.pais
Países Bajos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Hilversum
dc.description.fil
Fil: Cano Barquilla, Pilar. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Jimenez Ortega, Vanesa. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Scacchi Bernasconi, Pablo Antonio. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Esquifino, Ana Isabel. Universidad Complutense de Madrid; España
dc.journal.title
The Open Obesity Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://benthamopen.com/contents/pdf/TOOBESJ/TOOBESJ-2-1.pdf
Archivos asociados