Artículo
10-23 DNAzyme modified with (2′R)- and (2′S)-2′-deoxy- 2′-C-methyluridine in the catalytic core
Fecha de publicación:
08/2010
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Biorganic and Medicinal Chemistry Letters
ISSN:
0960-894X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The catalytic core of a 10-23 DNAzyme was modified using (2′R), (2′S)-2′-deoxy-2′-C-methyluridine and LNA-T. Catalytic activities under pseudo first order conditions were compared at different Mg 2+ concentrations, indicating that certain 2′-C-methyl modified DNAzymes have significant activities. Resistance against MCF-7 cell lysate and endonuclease RQ1 was also measured, showing that the introduction of 2′-C-methyl-2′-deoxynucleosides increased the stability.
Palabras clave:
10-23 DNAZYME
,
2′-DEOXY-2′-C-METHYL NUCLEOSIDES
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853.3Kb
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Licencia
Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción:
Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Robaldo, Laura; Montserrat, Javier Marcelo; Iribarren, Adolfo Marcelo; 10-23 DNAzyme modified with (2′R)- and (2′S)-2′-deoxy- 2′-C-methyluridine in the catalytic core; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 20; 15; 8-2010; 4367-4370
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