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dc.contributor.author
Leon, Wanda C.
dc.contributor.author
Bruno, Martin
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Allard, Simon
dc.contributor.author
Nader, Karim
dc.contributor.author
Cuello, A. Claudio
dc.date.available
2023-03-02T22:51:20Z
dc.date.issued
2010-06
dc.identifier.citation
Leon, Wanda C. ; Bruno, Martin; Allard, Simon; Nader, Karim; Cuello, A. Claudio; Engagement of the PFC in consolidation and recall of recent spatial memory; Cold Spring Harbor Laboratory Press; Learning & Memory (Cold Spring Harbor, N.Y.); 17; 6-2010; 297-305
dc.identifier.issn
1072-0502
dc.identifier.uri
http://hdl.handle.net/11336/189458
dc.description.abstract
The standard model of system consolidation proposes that memories are initially hippocampus dependent and become hippocampus independent over time. Previous studies have demonstrated the involvement of the medial prefrontal cortex (mPFC) in the retrieval of remote memories. The transformations required to make a memory undergo system's consolidation are thought to require synaptic plasticity. In this study, we investigated the participation of the mitogen-activated protein kinase (MAPK)/ERK pathway in acquisition, memory consolidation, and recent memory recall of the Morris water maze (MWM) task using a 1-d training protocol. To this end, bilateral injections of the MEK inhibitor U0126 into the rat mPFC were performed. The injection of the MEK inhibitor in the mPFC did not affect the acquisition of the MWM. However, MEK inhibitor resulted in impairments on recent memory retrieval either when applied at the end of the learning phase (memory consolidation) or prior to the retention test. The results strongly support the concept that recently acquired and consolidated spatial memories require the mPFC, and that local activation of the MAPK/ERK pathway in the mPFC is necessary for the consolidation and recall of recent memories.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cold Spring Harbor Laboratory Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Learning
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Memory
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Recall
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pre-frontal cortex
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Engagement of the PFC in consolidation and recall of recent spatial memory
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-02-16T13:40:40Z
dc.journal.volume
17
dc.journal.pagination
297-305
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Leon, Wanda C.. McGill University; Canadá
dc.description.fil
Fil: Bruno, Martin. McGill University; Canadá. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
dc.description.fil
Fil: Allard, Simon. McGill University; Canadá
dc.description.fil
Fil: Nader, Karim. McGill University; Canadá
dc.description.fil
Fil: Cuello, A. Claudio. McGill University; Canadá
dc.journal.title
Learning & Memory (Cold Spring Harbor, N.Y.)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://learnmem.cshlp.org/content/17/6/297
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1101/lm.1804410
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