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dc.contributor.author
Moretti, Franco
dc.contributor.author
Gómez Carrillo, Manuel
dc.contributor.author
Quarleri, Jorge Fabian
dc.date.available
2015-09-01T18:15:44Z
dc.date.issued
2013-03-06
dc.identifier.citation
Moretti, Franco; Gómez Carrillo, Manuel; Quarleri, Jorge Fabian; Longitudinal HIV-1 gp120-C2V3C3 phylogenetic surveillance and tropism evolution in patients under HAART; Springer; Virus Genes; 46; 3; 06-3-2013; 404-411
dc.identifier.issn
0920-8569
dc.identifier.uri
http://hdl.handle.net/11336/1892
dc.description.abstract
This 8-year longitudinal study was aimed to analyze the HIV-1 gp120-C2V3C3 sequence dynamics, their phylogenetic relationships and tropism evolution in patients under HAART. Such viral analysis comprised two compartments: plasma and PBMC. Fifty gp120-C2V3C3 genomic sequences were characterized from 16 patients: 41 from plasma when viremia was measurable and 9 from PBMCs if plasma viral load was undetectable. The vast majority of HIV isolates (43 out of 50) were ascribed to BF subtype, irrespective of the compartment (plasma or mononuclear-cells) analyzed. A statistically well-supported clustering phenomenon was observed for each patient sampling data. Each cluster comprised viral sequences from both compartments analyzed. In the vast majority of cases, the viral sequences obtained along active production periods were intermingled with those identified from proviral sequences. A substantial stability of co-receptor tropism for the HIV BF subtype was observed over an 8-year followup.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hiv
dc.subject
Gp120
dc.subject
V3 Loop
dc.subject
Tropism
dc.subject.classification
Virología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Longitudinal HIV-1 gp120-C2V3C3 phylogenetic surveillance and tropism evolution in patients under HAART
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1572-994X
dc.journal.volume
46
dc.journal.number
3
dc.journal.pagination
404-411
dc.journal.pais
Estados Unidos de América
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Moretti, Franco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina;
dc.description.fil
Fil: Gómez Carrillo, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina;
dc.description.fil
Fil: Quarleri, Jorge Fabian. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina;
dc.journal.title
Virus Genes
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/DOI:10.1007/s11262-013-0894-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://download.springer.com/static/pdf/466/art%253A10.1007%252Fs11262-013-0894-2.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs11262-013-0894-2&token2=exp=1441032487~acl=%2Fstatic%2Fpdf%2F466%2Fart%25253A10.1007%25252Fs11262-013-0894-2.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs11262-013-0894-2*~hmac=c72c2a1726be04f964d1dc0daabd7749143e9356204b85a71bd80052f5e8e6dd
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