Artículo
High ethanol dose during early adolescence induces locomotor activation and increases subsequent ethanol intake during late adolescence
Acevedo, María Belén
; Molina, Juan Carlos
; Nizhnikov, Michael E.; Spear, Norman E.; Pautassi, Ricardo Marcos
Fecha de publicación:
07/2010
Editorial:
John Wiley & Sons
Revista:
Developmental Psychobiology
ISSN:
0012-1630
e-ISSN:
1098-2302
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Adolescent initiation of ethanol consumption is associated with subsequent heightened probability of ethanol use disorders. The present study examined the relationship between motivational sensitivity to ethanol initiation in adolescent rats and later ethanol intake. Experiment 1 determined that ethanol induces locomotor activation shortly after administration but not if tested at a later post-administration interval. In Experiment 2, adolescent rats were assessed for ethanol-induced locomotor activation on postnatal Day 28. These animals were then evaluated for ethanol-mediated conditioned taste aversion and underwent a 16-day-long ethanol intake protocol. Ethanol-mediated aversive effects were unrelated to ethanol locomotor stimulation or subsequent ethanol consumption patterns. Ethanol intake during late adolescence was greatest in animals initiated to ethanol earliest at postnatal Day 28. Females that were more sensitive to ethanol's locomotor-activating effects showed a transient increase in ethanol selfadministration. Blood ethanol concentrations during initiation were not related to ethanol-induced locomotor activation. Adolescent rats appeared sensitive to the locomotor-stimulatory effects of ethanol. Even brief ethanol exposure during adolescence may promote later ethanol intake. © 2010 Wiley Periodicals, Inc.
Palabras clave:
ADOLESCENCE
,
CONDITIONED TASTE AVERSION
,
ETHANOL
,
ETHANOL INTAKE
,
RAT
,
REINFORCEMENT
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Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Acevedo, María Belén; Molina, Juan Carlos; Nizhnikov, Michael E.; Spear, Norman E.; Pautassi, Ricardo Marcos; High ethanol dose during early adolescence induces locomotor activation and increases subsequent ethanol intake during late adolescence; John Wiley & Sons; Developmental Psychobiology; 52; 5; 7-2010; 424-440
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