Artículo
Biotransformation of 2,6-diaminopurine nucleosides by immobilized Geobacillus stearothermophilus
de Benedetti, Eliana Celeste
; Rivero, Cintia Wanda
; Britos, Claudia Noelia
; Lozano, Mario Enrique
; Trelles, Jorge Abel
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Fecha de publicación:
09/2012
Editorial:
Wiley
Revista:
Biotechnology Progress
ISSN:
8756-7938
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
An efficient and green bioprocess to obtain 2,6-diaminopurine nucleosides using thermophilic bacteria is herein reported. Geobacillus stearothermophilus CECT 43 showed a conversion rate of 90 and 83% at 2 h to obtain 2,6-diaminopurine-2′-deoxyriboside and 2,6-diaminopurine riboside, respectively. The selected biocatalyst was successfully stabilized in an agarose matrix and used to produce up to 23.4 g of 2,6-diaminopurine-2′-deoxyriboside in 240 h of process. These nucleoside analogues can be used as prodrug precursors or in antisense oligonucleotide synthesis.
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Articulos(SEDE CENTRAL)
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Articulos de SEDE CENTRAL
Citación
de Benedetti, Eliana Celeste; Rivero, Cintia Wanda; Britos, Claudia Noelia; Lozano, Mario Enrique; Trelles, Jorge Abel; Biotransformation of 2,6-diaminopurine nucleosides by immobilized Geobacillus stearothermophilus; Wiley; Biotechnology Progress; 28; 5; 9-2012; 1251-1256
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