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Artículo

Evaluation of pathogenesis caused in cattle and guinea pig by a Mycobacterium bovis strain isolated from wild boar

Meikle, Virginia; Bianco, María V.; Blanco, Federico CarlosIcon ; Gioffré, Andrea KarinaIcon ; Garbaccio, Sergio Gabriel; Vagnoni, Lucas Emilio; Di Rienzo, Julio Alejandro; Canal, Ana; Bigi, FabianaIcon ; Cataldi, Ángel AdriánIcon
Fecha de publicación: 07/2011
Editorial: BioMed Central
Revista: BMC Veterinary Research
ISSN: 1746-6148
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Ciencias Veterinarias

Resumen

In many regions of the world, wild mammals act as reservoir of Mycobacterium bovis, a situation that prevents the eradication of bovine tuberculosis. In order to observe whether a strain isolated from a wild boar, previously tested as highly virulent in a mice model, is also virulent in cattle, we performed cattle experimental inoculation with this strain Groups of Friesian calves were either infected with the wild boar strain M. bovis 04-303 or with the bovine strain NCTC10772 as a control. We found that antigen-specific IFN-γ release in whole blood samples occurred earlier in animals infected with M. bovis 04-303. Both M. bovis strains resulted in a positive skin test, with animals infected with the wild boar isolate showing a stronger response. These results and the presence of more severe organ lesions, with granuloma and pneumonic areas in cattle demonstrate that the wild boar isolate is more virulent than the NCTC10772 strain. Additionally, we tested the infectivity of the M. bovis strains in guinea pigs and found that M. bovis 04-303 had the highest pathogenicity. M. bovis strains isolated from wild boars may be pathogenic for cattle, producing TB lesions.
Palabras clave: tuberculosis , hospedadores , virulencia , jabalí
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/188914
URL: https://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-7-37
DOI: http://dx.doi.org/10.1186/1746-6148-7-37
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Citación
Meikle, Virginia; Bianco, María V.; Blanco, Federico Carlos; Gioffré, Andrea Karina; Garbaccio, Sergio Gabriel; et al.; Evaluation of pathogenesis caused in cattle and guinea pig by a Mycobacterium bovis strain isolated from wild boar; BioMed Central; BMC Veterinary Research; 7; 7-2011; 1-7
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