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dc.contributor.author
Lendoire, Javier  
dc.contributor.author
Raffin, Gabriel  
dc.contributor.author
Bracco, Ricardo  
dc.contributor.author
Russi, Rodolfo  
dc.contributor.author
Ardiles, Victoria  
dc.contributor.author
Gondolesi, Gabriel Eduardo  
dc.contributor.author
Deflitto, Jorge  
dc.contributor.author
de Santibañez, Eduardo  
dc.contributor.author
Inventarza, Oscar  
dc.date.available
2023-02-23T14:26:45Z  
dc.date.issued
2011-10  
dc.identifier.citation
Lendoire, Javier; Raffin, Gabriel; Bracco, Ricardo; Russi, Rodolfo; Ardiles, Victoria; et al.; Caroli's disease: report of surgical options and long-term outcome of patients treated in Argentina. Multicenter study; Springer; Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract.; 15; 10; 10-2011; 1814-1819  
dc.identifier.issn
1091-255X  
dc.identifier.uri
http://hdl.handle.net/11336/188718  
dc.description.abstract
BACKGROUND: Caroli's disease (CD) management is still controversial. AIM: The purpose of this study is to report the most frequent clinical features, treatment options, and outcome obtained after surgical management of CD. METHODS: A voluntary survey was conducted. Demographic, clinical, surgical, and pathological variables were analyzed. RESULTS: Six centers included 24 patients having received surgical treatment from 1991 to 2009. Seventeen (70.8%) patients were female, with average age of 48.7 years old (20-71), and 95.5% were symptomatic. There was left hemiliver involvement in 75% of the patients. Surgical procedures included nine left lateral sectionectomies, eight left hepatectomies, and four right hepatectomies for those with hemiliver disease, while for patients with bilateral disease, one right hepatectomy and two Roux-en-Y hepaticojejunostomies were performed. The average length of hospitalization was 7 days. For perioperative complications (25%), three patients presented minor complications (types 1-2), while major complications occurred in three patients (type 3a). No mortality was reported. After a median follow-up of 166 months, all patients are alive and free of symptoms. CD diagnosis was confirmed by histology. Congenital hepatic fibrosis was present in two patients (8.3%) and cholangiocarcinoma in one (4.2%). CONCLUSIONS: CD in Argentina is more common in females with left hemiliver involvement. Surgical resection is the best curative option in unilateral disease, providing long-term survival free of symptoms and complications. In selected cases of bilateral disease without parenchymal involvement, hepaticojejunostomy should be proposed. However, a close follow-up is mandatory because patients might progress and a transplant should be indicated.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ENFERMEDAD DE CAROLI  
dc.subject
CIRUGIA  
dc.subject
HEPATECTOMIA  
dc.subject
TRANSPLANTE  
dc.subject.classification
Cirugía  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Caroli's disease: report of surgical options and long-term outcome of patients treated in Argentina. Multicenter study  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-02-21T22:15:51Z  
dc.journal.volume
15  
dc.journal.number
10  
dc.journal.pagination
1814-1819  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlin  
dc.description.fil
Fil: Lendoire, Javier. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina  
dc.description.fil
Fil: Raffin, Gabriel. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina  
dc.description.fil
Fil: Bracco, Ricardo. No especifíca;  
dc.description.fil
Fil: Russi, Rodolfo. Ministerio de Defensa. Armada Argentina. Hospital Naval Buenos Aires Cirujano Mayor Dr. Pedro Mallo; Argentina  
dc.description.fil
Fil: Ardiles, Victoria. Hospital Italiano; Argentina  
dc.description.fil
Fil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Deflitto, Jorge. No especifíca;  
dc.description.fil
Fil: de Santibañez, Eduardo. Hospital Italiano; Argentina  
dc.description.fil
Fil: Inventarza, Oscar. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina  
dc.journal.title
Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract.  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s11605-011-1620-9  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11605-011-1620-9