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dc.contributor.author
Hutson, J. R.
dc.contributor.author
Lubetsky, A.
dc.contributor.author
Walfisch, A.
dc.contributor.author
Ballios, B. G.
dc.contributor.author
Garcia Bournissen, Facundo
dc.contributor.author
Koren, G.
dc.date.available
2023-02-23T13:56:47Z
dc.date.issued
2011-11
dc.identifier.citation
Hutson, J. R.; Lubetsky, A.; Walfisch, A.; Ballios, B. G.; Garcia Bournissen, Facundo; et al.; The transfer of 6-mercaptopurine in the dually perfused human placenta; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 32; 3; 11-2011; 349-353
dc.identifier.issn
0890-6238
dc.identifier.uri
http://hdl.handle.net/11336/188709
dc.description.abstract
The immunosuppressant azathioprine is increasingly being used in pregnancy. The human placenta is considered a relative barrier to the major metabolite, 6-mercaptopurine (6-MP), and likely explains the lack of proven teratogenicity in humans. The aim of this study was to determine how the human placenta restricts 6-MP transfer using the human placental perfusion model. After addition of 50. ng/ml (n=4) and 500. ng/ml (n=3) 6-MP into the maternal circulation, there was a biphasic decline in its concentration and a delay in fetal circulation appearance. Under equilibrative conditions, the fetal-to-maternal concentration ratio was >1.0 as a result of ion trapping. Binding to placental tissue and maternal pharmacokinetic parameters are the main factors that restrict placental transfer of 6-MP. Active transport is unlikely to play a significant role and drug interactions involving, or polymorphisms in, placental drug efflux transporters are not likely to put the fetus at risk of higher 6-MP exposure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
6-MERCAPTOPURINE
dc.subject
AZATHIOPRINE
dc.subject
PLACENTA
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PLACENTAL PERFUSION
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PREGNANCY
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The transfer of 6-mercaptopurine in the dually perfused human placenta
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-02-21T22:17:15Z
dc.journal.volume
32
dc.journal.number
3
dc.journal.pagination
349-353
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Hutson, J. R.. University of Toronto; Canadá. University Of Toronto. Hospital For Sick Children; Canadá
dc.description.fil
Fil: Lubetsky, A.. University Of Toronto. Hospital For Sick Children; Canadá
dc.description.fil
Fil: Walfisch, A.. University Of Toronto. Hospital For Sick Children; Canadá
dc.description.fil
Fil: Ballios, B. G.. University of Toronto; Canadá
dc.description.fil
Fil: Garcia Bournissen, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Koren, G.. University of Toronto; Canadá. University Of Toronto. Hospital For Sick Children; Canadá
dc.journal.title
Reproductive Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S089062381100356X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.reprotox.2011.08.008
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