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dc.contributor.author
Gessaghi, Valeria Cristina
dc.contributor.author
Raschi, Marcelo A.
dc.contributor.author
Tanoni, Debora Y.
dc.contributor.author
Perazzo, Carlos Alberto
dc.contributor.author
Larreteguy, Axel Eduardo
dc.date.available
2023-02-23T13:56:31Z
dc.date.issued
2011-06
dc.identifier.citation
Gessaghi, Valeria Cristina; Raschi, Marcelo A.; Tanoni, Debora Y.; Perazzo, Carlos Alberto; Larreteguy, Axel Eduardo; Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation; Elsevier Science SA; Computer Methods in Applied Mechanics and Engineering; 200; 23-24; 6-2011; 2117-2125
dc.identifier.issn
0045-7825
dc.identifier.uri
http://hdl.handle.net/11336/188708
dc.description.abstract
Atherosclerosis is one of the leading causes of death in the first world countries nowadays. It is a vascular disease that affects medium and large size arteries, involving the formation of plaques within the artery wall. These plaques result from the accumulation of fat, cholesterol, cell debris, smooth muscle cells and other cells and substances, and may cause temporary or definitive lack of blood supply to an organ.This article proposes a model for cholesterol accumulation and plaque growth. The model is basically a mass balance of low density lipoproteins (LDL) in the intima. The inflow, outflow, oxidation, and consumption of LDL is modeled combining partial models and correlations available in the literature.The model was implemented into an open source finite volume code. Assuming steady blood flow, the code was used to predict lesion formation on a three-dimensional model of the carotid artery bifurcation, a location greatly studied for its role in supplying blood to some parts of the brain and for being related to strokes due to formation of atheromas. The simulation was carried out under physiologic conditions for blood pressure and LDL blood concentration.Results for LDL mass accumulation and intimal thickening over time, plaque shape, and location of thicker spots are reported, showing that the proposed model approximates reasonably well the intimal thickening obtained from post-mortem aortic fatty streaks and from B-mode ultrasonography of the carotid artery of healthy subjects reported by other authors.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science SA
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ATHEROSCLEROSIS
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CHOLESTEROL TRANSPORT
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HEMODYNAMICS
dc.subject.classification
Física de los Fluidos y Plasma
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Ciencias Físicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-02-21T22:15:53Z
dc.journal.volume
200
dc.journal.number
23-24
dc.journal.pagination
2117-2125
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Gessaghi, Valeria Cristina. Universidad Nacional de la Pampa. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Raschi, Marcelo A.. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; Argentina
dc.description.fil
Fil: Tanoni, Debora Y.. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; Argentina
dc.description.fil
Fil: Perazzo, Carlos Alberto. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Larreteguy, Axel Eduardo. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; Argentina
dc.journal.title
Computer Methods in Applied Mechanics and Engineering
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S004578251100106X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cma.2011.03.001
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