Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina

Trypanosoma cruzi-specific immune responses were evaluated in a total of 88 subjects living in areas endemic of Chagas disease of Argentina by IFN-γ ELISPOT assays and immunoblotting. Positive T. cruzi antigen-induced IFN-γ responses were detected in 42% of subjects evaluated (15/26 positive by conventional serology and 22/62 seronegative subjects). Using immunoblotting, T. cruzi-specific IgG reactivity was detected in all seropositive subjects and in 11% (7/61) of subjects negative by conventional serology. Measurements of T cell responses and antibodies by immunoblotting, in conjunction with conventional serology, might enhance the capability of detection of exposure to T. cruzi in endemic areas.

Palabras clave: HUMORAL RESPONSES , T CELL RESPONSES , TRYPANOSOMA CRUZI

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/188505

URL: https://www.sciencedirect.com/science/article/abs/pii/S1286457910000298

DOI: http://dx.doi.org/10.1016/j.micinf.2010.01.011

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Citación

Olivera, Gabriela Carina; Albareda, María Cecilia; Alvarez, Maria G.; de Rissio, Ana María; Fichera, Laura Edith; et al.; Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina; Elsevier Science; Microbes and Infection; 12; 5; 5-2010; 359-363

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