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dc.contributor.author
Granero, Gladys Ester
dc.contributor.author
Longhi, Marcela Raquel
dc.date.available
2023-02-17T20:10:56Z
dc.date.issued
2010-06-22
dc.identifier.citation
Granero, Gladys Ester; Longhi, Marcela Raquel; Promising complexes of acetazolamide for topical ocular administration; Taylor & Francis; Expert Opinion on Drug Delivery; 7; 8; 22-6-2010; 943-953
dc.identifier.issn
1742-5247
dc.identifier.uri
http://hdl.handle.net/11336/188492
dc.description.abstract
Importance of the field: Acetazolamide (ACZ), a carbonic anhydrase inhibitor (CAI), and other oral CAIs have been an integral part of antiglaucoma therapy for > 40 years. ACZ is used orally for the reduction of intraocular pressure in patients suffering from glaucoma. However, this treatment leads to unpleasant systemic side effects. The answer to the undesirable effects of ACZ is the topical delivery of this drug into the eye, where it could elicit its physiological action. However, the development of a topical formulation of ACZ is limited by its poor ocular bioavailability, which can be largely attributed to its poor penetration coefficient and poor biphasic solubility. Areas covered in this review: This review offers an overview of different approaches to delivering ACZ to the eye, highlighting the potential of the ternary system ACZ:HP-β-CD:TEA as a tool for formulating aqueous ACZ eye drop solutions. What the reader will gain: A critical analysis is provided to highlight the key issues to design formulations containing hydrophilic cyclodextrins. Take home message: The ACZ:HP-β-CD:TEA complex is an important new approach to improve the ocular bioavailability of this drug. This approach may be applied to other CAIs in the future.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACETAZOLAMIDE
dc.subject
CYCLODEXTRINS
dc.subject
MULTICOMPONENT INCLUSION COMPLEXES
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OPHTHALMIC DRUG DELIVERY SYSTEM
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Nano-procesamiento
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Nanotecnología
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Promising complexes of acetazolamide for topical ocular administration
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-02-07T11:57:02Z
dc.identifier.eissn
1744-7593
dc.journal.volume
7
dc.journal.number
8
dc.journal.pagination
943-953
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.journal.title
Expert Opinion on Drug Delivery
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1517/17425247.2010.497536
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1517/17425247.2010.497536
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