Artículo
Ultra-small solid archaeolipid nanoparticles for active targeting to macrophages of the inflamed mucosa
Higa, Leticia Herminia
; Jerez, Horacio Emanuel
; de Farias, Marcelo Alexandre; Portugal, Rodrigo Villares; Romero, Eder Lilia
; Morilla, María José
Fecha de publicación:
04/2017
Editorial:
Future Medicine
Revista:
Nanomedicine
ISSN:
1743-5889
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Aim: Develop nanoparticulate agents for oral targeted delivery of dexamethasone (Dex) to macrophages of inflamed mucosa. Materials & methods: Solid archaeolipid nanoparticles (SAN-Dex) (compritol/Halorubrum tebenquichense polar archaeolipids/soybean phosphatidylcholine/Tween-80 4; 0.9; 0.3; 3% w/w) loaded with Dex were prepared. Their mucopenetration, stability under digestion and in vitro anti-inflammatory activity, were determined. Results: Ultra-small SAN-Dex strongly reduced the levels of TNF-α, IL-6 and IL-12 on J774A1 cells stimulated with lipopolysaccharides as compared with free Dex or loaded in ordinary solid lipid nanoparticles-Dex. After in vitro digestion, the anti-inflammatory activity of SAN-Dex was retained, while that of solid lipid nanoparticles-Dex was lost. Conclusion: Because of their structural and pharmacodynamic features, SAN-Dex may be suitable for oral targeted delivery to inflamed mucosa.
Palabras clave:
DIGESTION STABILITY
,
INFLAMMATORY BOWEL DISEASE
,
ORAL DELIVERY
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Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Higa, Leticia Herminia; Jerez, Horacio Emanuel; de Farias, Marcelo Alexandre; Portugal, Rodrigo Villares; Romero, Eder Lilia; et al.; Ultra-small solid archaeolipid nanoparticles for active targeting to macrophages of the inflamed mucosa; Future Medicine; Nanomedicine; 12; 10; 4-2017; 1165-1175
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