Mostrar el registro sencillo del ítem
dc.contributor.author
Delbes, G.
dc.contributor.author
Blázquez, M.
dc.contributor.author
Fernandino, Juan Ignacio
dc.contributor.author
Grigorova, P.
dc.contributor.author
Hales, B. F.
dc.contributor.author
Metcalfe, C.
dc.contributor.author
Navarro Martín, L.
dc.contributor.author
Parent, L.
dc.contributor.author
Robaire, B.
dc.contributor.author
Rwigemera, A.
dc.contributor.author
Van Der Kraak, G.
dc.contributor.author
Wade, M.
dc.contributor.author
Marlatt, V.
dc.date.available
2023-02-17T11:10:03Z
dc.date.issued
2022-03
dc.identifier.citation
Delbes, G.; Blázquez, M.; Fernandino, Juan Ignacio; Grigorova, P.; Hales, B. F.; et al.; Effects of endocrine disrupting chemicals on gonad development: Mechanistic insights from fish and mammals; Academic Press Inc Elsevier Science; Environmental Research; 204; 3-2022; 1-24
dc.identifier.issn
0013-9351
dc.identifier.uri
http://hdl.handle.net/11336/188335
dc.description.abstract
Over the past century, evidence has emerged that endocrine disrupting chemicals (EDCs) have an impact on reproductive health. An increased frequency of reproductive disorders has been observed worldwide in both wildlife and humans that is correlated with accidental exposures to EDCs and their increased production. Epidemiological and experimental studies have highlighted the consequences of early exposures and the existence of key windows of sensitivity during development. Such early in life exposures can have an immediate impact on gonadal and reproductive tract development, as well as on long-term reproductive health in both males and females. Traditionally, EDCs were thought to exert their effects by modifying the endocrine pathways controlling reproduction. Advances in knowledge of the mechanisms regulating sex determination, differentiation and gonadal development in fish and rodents have led to a better understanding of the molecular mechanisms underlying the effects of early exposure to EDCs on reproduction. In this manuscript, we review the key developmental stages sensitive to EDCs and the state of knowledge on the mechanisms by which model EDCs affect these processes, based on the roadmap of gonad development specific to fish and mammals.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DEVELOPMENT
dc.subject
ENDOCRINE DISRUPTING CHEMICALS
dc.subject
FISH
dc.subject
GONADAL DIFFERENTIATION
dc.subject
MAMMALS
dc.subject
OVARY
dc.subject
SEX DETERMINATION
dc.subject
TESTIS
dc.subject.classification
Biología del Desarrollo
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Effects of endocrine disrupting chemicals on gonad development: Mechanistic insights from fish and mammals
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-02-09T15:41:37Z
dc.journal.volume
204
dc.journal.pagination
1-24
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Delbes, G.. Centre Armand-frappier Santé Biotechnologie ; Institut National de Recherche Scientifique;
dc.description.fil
Fil: Blázquez, M.. Consejo Superior de Investigaciones Científicas. Instituto de Ciencias del Mar; España
dc.description.fil
Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
dc.description.fil
Fil: Grigorova, P.. Université Teluq; Canadá
dc.description.fil
Fil: Hales, B. F.. McGill University; Canadá
dc.description.fil
Fil: Metcalfe, C.. Trent University; Canadá
dc.description.fil
Fil: Navarro Martín, L.. Institute of Environmental Assessment and Water Research; España
dc.description.fil
Fil: Parent, L.. Université Teluq; Canadá
dc.description.fil
Fil: Robaire, B.. McGill University; Canadá
dc.description.fil
Fil: Rwigemera, A.. Centre Armand-frappier Santé Biotechnologie ; Institut National de Recherche Scientifique;
dc.description.fil
Fil: Van Der Kraak, G.. University of Guelph; Canadá
dc.description.fil
Fil: Wade, M.. Health Canada; Canadá
dc.description.fil
Fil: Marlatt, V.. University Fraser Simon; Canadá
dc.journal.title
Environmental Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0013935121013359
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.envres.2021.112040
Archivos asociados