Artículo
Response surface method applied to the optimization of estradiol permeation in chitosan membranes
Fecha de publicación:
06/2012
Editorial:
Springer
Revista:
Bulletin Of Materials Science
ISSN:
0250-4707
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The present work deals with the study of estradiol permeation in chitosan membranes. A fractional factorial design was built for the determination of the main factors affecting estradiol permeation. The independent factors analysed were: concentration of chitosan, concentration of cross-linking agent, cross-linking time and thermal treatment. It was found that concentration of chitosan and cross-linking time significantly affected the response. The effects of thermal treatment and concentration of cross-linking agent were not significant. An optimization process based on response surface methodology was carried out in order to develop a statistical model which describes the relationship between active independent variables and estradiol flux. This model can be used to find out a combination of factor levels during response optimization. Possible options for response optimization are to maximize, minimize or move towards a target value.
Palabras clave:
Chitosan
,
Dry Heat
,
Mass Transport
,
Membranes
,
Water Sorption
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Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Mengatto, Luciano Nicolas; Cabrera, Maria Ines; Luna, Julio Alberto; Response surface method applied to the optimization of estradiol permeation in chitosan membranes; Springer; Bulletin Of Materials Science; 35; 3; 6-2012; 481-487
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