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dc.contributor.author
Prokopez, Cintia R.  
dc.contributor.author
Farinola, Romina  
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Vallejos, Miguel  
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Lopredo, Lorena S.  
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Sfriso, Luciano E.  
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Chiapella, Luciana Carla  
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Arce, Claudio  
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Corral, Ricardo M.  
dc.contributor.author
Cuesta, Manuel J.  
dc.contributor.author
Alomo, Martín  
dc.date.available
2023-02-10T18:46:28Z  
dc.date.issued
2022-03  
dc.identifier.citation
Prokopez, Cintia R.; Farinola, Romina; Vallejos, Miguel; Lopredo, Lorena S.; Sfriso, Luciano E.; et al.; Olanzapine, risperidone and quetiapine: Do these atypical antipsychotics have a protective effect for SARS-CoV-2?; Elsevier Science; Schizophrenia Research; 241; 3-2022; 140-141  
dc.identifier.issn
0920-9964  
dc.identifier.uri
http://hdl.handle.net/11336/187679  
dc.description.abstract
It was proposed that antipsychotics drugs (APDs) could have anti SARS-CoV-2 properties and different mechanisms were described to explain this antiviral effect (Gordon et al., 2020b; Javelot et al., 2020; Plaze et al., 2020). Two articles using the comparative viral-human protein-protein interaction map revealed that the sigma-1 receptor (SIGMA1R), located in the endoplasmic reticulum, caused reductions in SARS-CoV-2 replication, and proposed haloperidol as a potential anti SARS-CoV-2 for its effect on this receptor (Gordon et al., 2020, Gordon et al., 2020). Another mechanism proposed by which antipsychotics could have antiviral properties is through the inhibition of clathrin-mediated endocytosis (de Pellón Santamaría, 2020; Villoutreix et al., 2020). Also, it was described that cationic amphiphilic drugs (CAD), like numerous APDs, may have antiviral effects (Vaugeois, 2020). On the other side, antipsychotics suppress the expression of pro-inflammatory cytokines and these anti-inflammatory effects are elicited through the reduction of pro-inflammatory cytokines production, like IL-1A, IL-6, and TNF-α (Obuchowicz et al., 2017). Growing evidence suggests that antipsychotics have anti-inflammatory properties that may attenuate the normal defensive function of the immune system and possibly reduce the uncontrolled inflammatory responses, such as seen in severe SARS-CoV-2 (Juncal-Ruiz et al., 2018).  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
OLANZAPINE  
dc.subject
RISPERIDONE  
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QUETIAPINE  
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COVID-19  
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SARS-COV-2  
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Farmacología y Farmacia  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Psiquiatría  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Olanzapine, risperidone and quetiapine: Do these atypical antipsychotics have a protective effect for SARS-CoV-2?  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-02-09T15:26:38Z  
dc.journal.volume
241  
dc.journal.pagination
140-141  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Prokopez, Cintia R.. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital Neuropsiquiatrico Braulio Aurelio Moyano.; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacología; Argentina  
dc.description.fil
Fil: Farinola, Romina. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina  
dc.description.fil
Fil: Vallejos, Miguel. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina  
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Fil: Lopredo, Lorena S.. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital Neuropsiquiatrico Braulio Aurelio Moyano.; Argentina  
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Fil: Sfriso, Luciano E.. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital Neuropsiquiatrico Braulio Aurelio Moyano.; Argentina  
dc.description.fil
Fil: Chiapella, Luciana Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina  
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Fil: Arce, Claudio. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital Neuropsiquiatrico Braulio Aurelio Moyano.; Argentina  
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Fil: Corral, Ricardo M.. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina  
dc.description.fil
Fil: Cuesta, Manuel J.. Complejo Hospitalario de Navarra; España. Instituto de Investigación Sanitaria de Navarra; España  
dc.description.fil
Fil: Alomo, Martín. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital Neuropsiquiatrico Braulio Aurelio Moyano.; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina  
dc.journal.title
Schizophrenia Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0920996422000457  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.schres.2022.01.035