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dc.contributor.author
Xavier, Mariana
dc.contributor.author
Farez, Nayla
dc.contributor.author
Salvatierra, Paola Luciana
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dc.contributor.author
Jardini, Andre Luiz
dc.contributor.author
Kharmandayan, Paulo
dc.contributor.author
Feldman, Sara
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dc.date.available
2023-02-10T18:40:16Z
dc.date.issued
2022-02
dc.identifier.citation
Xavier, Mariana; Farez, Nayla; Salvatierra, Paola Luciana; Jardini, Andre Luiz; Kharmandayan, Paulo; et al.; Biological performance of a bioabsorbable Poly (L-Lactic Acid) produced in polymerization unit: in vivo studies; F1000 Research Ltd; F1000Research; 10; 2-2022; 1-18
dc.identifier.uri
http://hdl.handle.net/11336/187675
dc.description.abstract
Background: The biomaterials engineering goal is to manufacture a biocompatible scaffold that adequately supports or improves tissue regeneration after implantation of the biomaterial in the injured area. Many requirements are demanded for a biomaterial, such as biocompatibility, elasticity, degradation time, and a very important factor is its cost of importation or synthesis, making its application inaccessible to some countries. Studies about biomaterials market show that Polylactic acid (PLLA) is one of the most used polymers, but expensive to produce. It becomes important to prove the biocompatibility of the new PLLA and to find strategies to produce biocompatible biopolymers at an acceptable production cost. Methods: In this work, the polylactic acid biomaterial was synthesized by ring-opening polymerization. The polymer was submitted to initial in vivo biocompatibility studies in 12 New Zealand female rabbits, assigned to two groups: (1) Lesion and PLLA group (n = 6), (2) Lesion No PLLA group (n = 6). Each group was divided into two subgroups at six and nine months post-surgical time. Before euthanasia clinical and biochemical studies were performed and after that tomographic (CT), histological (Hematoxylin and Eosin and Masson's trichrome) and histomorphometric analyses were performed to evaluate the injury site and prove biocompatibility. The final cost of this polymer was analyzed. Results: The statistical studies of hemogram and hepatocyte enzymes, showed that there were no significant differences between the groups for any of the times studied, in any of the variables considered and the results of CT and histology showed that there was an important process of neoregeneration. The cost analysis showed the biopolymer synthesis is between R$3,06 - R$5,49 cheaper than the import cost. Conclusions: It was possible to synthesize the PLLA biopolymer by cyclic ring opening, which proved to be biocompatible, potential osteoregenerative and cheaper than other imported biopolymers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
F1000 Research Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BIOFABRICATION
dc.subject
BIOMATERIALS
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MATERIAL SYNTHESIS
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ORTHOPEDIC
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PLLA
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POLYMERS
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TISSUE-ENGINEERING
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Otras Biotecnologías de la Salud
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dc.subject.classification
Biotecnología de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Biological performance of a bioabsorbable Poly (L-Lactic Acid) produced in polymerization unit: in vivo studies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-02-09T15:50:27Z
dc.identifier.eissn
2046-1402
dc.journal.volume
10
dc.journal.pagination
1-18
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Xavier, Mariana. Institute Of Biofabrication; Brasil. Universidade Estadual de Campinas; Brasil
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Fil: Farez, Nayla. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
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Fil: Salvatierra, Paola Luciana. Universidad Nacional de Villa María. Instituto Académico Pedagógico de Ciencias Básicas y Aplicadas; Argentina
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Fil: Jardini, Andre Luiz. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
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Fil: Kharmandayan, Paulo. Institute Of Biofabrication; Brasil. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
dc.journal.title
F1000Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://f1000research.com/articles/10-1275/v1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.12688/f1000research.73754.1
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