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dc.contributor.author
Ramirez, Karina  
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Ditamo, Yanina  
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Galen, James E.  
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Baillie, Les W.J.  
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Pasetti, Marcela F.  
dc.date.available
2023-02-07T13:56:43Z  
dc.date.issued
2010-07  
dc.identifier.citation
Ramirez, Karina; Ditamo, Yanina; Galen, James E.; Baillie, Les W.J.; Pasetti, Marcela F.; Mucosal priming of newborn mice with S. Typhi Ty21a expressing anthrax protective antigen (PA) followed by parenteral PA-boost induces B and T cell-mediated immunity that protects against infection by passing maternal antibodies; Elsevier; Vaccine; 28; 37; 7-2010; 6065-6075  
dc.identifier.issn
0264-410X  
dc.identifier.uri
http://hdl.handle.net/11336/187182  
dc.description.abstract
The currently licensed anthrax vaccine has several limitations and its efficacy has been proven only in adults. Effective immunization of newborns and infants requires adequate stimulation of their immune system, which is competent but not fully activated. We explored the use of the licensed live attenuated S. Typhi vaccine strain Ty21a expressing Bacillus anthracis protective antigen [Ty21a(PA)] followed PAalum as a strategy for immunizing the pediatric population. Newborn mice primed with a single dose of Ty21a(PA) exhibited high frequencies of mucosal IgA-secreting B cells and IFN--secreting T cells during the neonatal period, none of which was detected in newborns immunized with a single dose of PA-alum. Priming with Ty21a(PA) followed by PA-boost resulted in high levels of PA-specific IgG, toxin neutralizing and opsonophagocytic antibodies and increased frequency of bone marrow IgG plasma cells and memory B cells compared with repeated immunization with PA-alum alone. Robust B and T cell responses developed even in the presence of maternal antibodies. The prime-boost protected against systemic and respiratory infection. Mucosal priming with a safe and effective S. Typhi-based anthrax vaccine followed by PA-boost could serve as a practical and effective prophylactic approach to prevent anthrax early in life.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
ANTHRAX VACCINES  
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NEWBORN MICE  
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PRIME-BOOST IMMUNIZATION  
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S. TYPHI LIVE VECTORS  
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Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Mucosal priming of newborn mice with S. Typhi Ty21a expressing anthrax protective antigen (PA) followed by parenteral PA-boost induces B and T cell-mediated immunity that protects against infection by passing maternal antibodies  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
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info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-02-02T23:11:53Z  
dc.identifier.eissn
1873-2518  
dc.journal.volume
28  
dc.journal.number
37  
dc.journal.pagination
6065-6075  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Ámsterdam  
dc.description.fil
Fil: Ramirez, Karina. University of Maryland; Estados Unidos  
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Fil: Ditamo, Yanina. University of Maryland; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina  
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Fil: Galen, James E.. University of Maryland; Estados Unidos  
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Fil: Baillie, Les W.J.. Cardiff University; Reino Unido  
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Fil: Pasetti, Marcela F.. University of Maryland; Estados Unidos  
dc.journal.title
Vaccine  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0264410X10009308  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vaccine.2010.06.089