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dc.contributor.author
Ramirez, Karina
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Ditamo, Yanina
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Galen, James E.
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Baillie, Les W.J.
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Pasetti, Marcela F.
dc.date.available
2023-02-07T13:56:43Z
dc.date.issued
2010-07
dc.identifier.citation
Ramirez, Karina; Ditamo, Yanina; Galen, James E.; Baillie, Les W.J.; Pasetti, Marcela F.; Mucosal priming of newborn mice with S. Typhi Ty21a expressing anthrax protective antigen (PA) followed by parenteral PA-boost induces B and T cell-mediated immunity that protects against infection by passing maternal antibodies; Elsevier; Vaccine; 28; 37; 7-2010; 6065-6075
dc.identifier.issn
0264-410X
dc.identifier.uri
http://hdl.handle.net/11336/187182
dc.description.abstract
The currently licensed anthrax vaccine has several limitations and its efficacy has been proven only in adults. Effective immunization of newborns and infants requires adequate stimulation of their immune system, which is competent but not fully activated. We explored the use of the licensed live attenuated S. Typhi vaccine strain Ty21a expressing Bacillus anthracis protective antigen [Ty21a(PA)] followed PAalum as a strategy for immunizing the pediatric population. Newborn mice primed with a single dose of Ty21a(PA) exhibited high frequencies of mucosal IgA-secreting B cells and IFN--secreting T cells during the neonatal period, none of which was detected in newborns immunized with a single dose of PA-alum. Priming with Ty21a(PA) followed by PA-boost resulted in high levels of PA-specific IgG, toxin neutralizing and opsonophagocytic antibodies and increased frequency of bone marrow IgG plasma cells and memory B cells compared with repeated immunization with PA-alum alone. Robust B and T cell responses developed even in the presence of maternal antibodies. The prime-boost protected against systemic and respiratory infection. Mucosal priming with a safe and effective S. Typhi-based anthrax vaccine followed by PA-boost could serve as a practical and effective prophylactic approach to prevent anthrax early in life.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ANTHRAX VACCINES
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NEWBORN MICE
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PRIME-BOOST IMMUNIZATION
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S. TYPHI LIVE VECTORS
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Mucosal priming of newborn mice with S. Typhi Ty21a expressing anthrax protective antigen (PA) followed by parenteral PA-boost induces B and T cell-mediated immunity that protects against infection by passing maternal antibodies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-02-02T23:11:53Z
dc.identifier.eissn
1873-2518
dc.journal.volume
28
dc.journal.number
37
dc.journal.pagination
6065-6075
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Ramirez, Karina. University of Maryland; Estados Unidos
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Fil: Ditamo, Yanina. University of Maryland; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
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Fil: Galen, James E.. University of Maryland; Estados Unidos
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Fil: Baillie, Les W.J.. Cardiff University; Reino Unido
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Fil: Pasetti, Marcela F.. University of Maryland; Estados Unidos
dc.journal.title
Vaccine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0264410X10009308
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vaccine.2010.06.089
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