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dc.contributor.author
Simioni, Yamila Roxana
dc.contributor.author
Perez, Noelia Soledad
dc.contributor.author
Barbosa, Leandro R. S.
dc.contributor.author
Perez, Ana Paula
dc.contributor.author
Schilrreff, Priscila
dc.contributor.author
Romero, Eder Lilia
dc.contributor.author
Morilla, María José
dc.date.available
2023-02-07T11:28:09Z
dc.date.issued
2022-07
dc.identifier.citation
Simioni, Yamila Roxana; Perez, Noelia Soledad; Barbosa, Leandro R. S.; Perez, Ana Paula; Schilrreff, Priscila; et al.; Enhancing the anti-psoriatic activity of vitamin D3 employing nanostructured archaeolipid carriers; Editions Sante; Journal of Drug Delivery Science and Technology; 73; 103455; 7-2022; 1-11
dc.identifier.issn
1773-2247
dc.identifier.uri
http://hdl.handle.net/11336/187089
dc.description.abstract
Psoriasis (Ps) is a multifactorial autoimmune skin disease, where oxidative stress plays a key role in promoting a vicious producing cycle between keratinocytes and immune cells. Vitamin D3 (VD3) regulates the differentiation, apoptosis, and proliferation of keratinocytes, also displaying antioxidant and anti-inflammatory activities. Previous attempts of using topical VD3 as anti-psoriatic agent, failed because of its poor solubility, high hydrophobicity, structural lability, and low bioavailability. Specifically tailored nanoparticles for topical co-delivery of VD3 and antioxidants to activated keratinocytes and macrophages could make Ps treatments more efficient. In this work, structural features, and in vitro activity of nanostructured archaeolipid carriers (NAC) containing VD3 plus the antioxidant C50 dipolar carotenoid bacterioruberin (BR) (NAC-VD3), are presented. Ultra-small (70 nm), −39 mV ζ potential, ∼5 mg VD3/ml, 0.35 BR μg/ml NAC-VD3, with good storage stability (at least 6 month) consisted of a compritol and BR core, covered by a shell of sn 2,3 ether linked archaeolipids and Tween 80 (2: 2: 1.2: 3% w/w) were obtained. Raman, DSC and SAXS analysis showed that VD3 was trapped within the disordered compritol-BR core, impairing its fast release, and protecting VD3 against thermal degradation. NAC-VD3 were extensively captured and displayed high anti-proliferative (65%), anti-inflammatory (IL-8 release) and antioxidant activities (ROS reduction) on a psoriatic model made of CaCl2 differentiated-imiquimod stimulated HaCaT cells, and on lipopolysaccharide induced THP-1 macrophages. Interestingly, the BR extract alone displayed high anti-Staphylococcus aureus activity including anti-biofilm formation. Overall, the results suggest that NAC-VD3 protect the labile structure of VD3, while enhancing its anti-psoriatic activity and deserves further in vivo exploration.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Editions Sante
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTI-INFLAMMATORY
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BACTERIORUBERIN
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STAPHYLOCOCCUS AUREUS
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Otras Nanotecnología
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Enhancing the anti-psoriatic activity of vitamin D3 employing nanostructured archaeolipid carriers
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-02-02T23:19:46Z
dc.journal.volume
73
dc.journal.number
103455
dc.journal.pagination
1-11
dc.journal.pais
Países Bajos
dc.description.fil
Fil: Simioni, Yamila Roxana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Perez, Noelia Soledad. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Barbosa, Leandro R. S.. Laboratorio Nacional de Luz Sincrotron; Brasil. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Perez, Ana Paula. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
dc.description.fil
Fil: Schilrreff, Priscila. Freie Universität Berlin; Alemania. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Romero, Eder Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
dc.description.fil
Fil: Morilla, María José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Journal of Drug Delivery Science and Technology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jddst.2022.103455
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1773224722003653
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