Artículo
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
Cafaro, Thamara Analia
; Santo, Stefanía; Robles, Lucena A.; Crim, Nicolás; Urrets Zavalía, Julio Alberto; Serra, Horacio Marcelo
Fecha de publicación:
17/08/2010
Editorial:
Molecular Vision
Revista:
Molecular Vision
ISSN:
1090-0535
e-ISSN:
1090-0535
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Purpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. Methods: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. Results: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG). Conclusions: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline.
Palabras clave:
GLAUCOMA
,
PAD2
,
ETHIOLOGY
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Citación
Cafaro, Thamara Analia; Santo, Stefanía; Robles, Lucena A.; Crim, Nicolás; Urrets Zavalía, Julio Alberto; et al.; Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve; Molecular Vision; Molecular Vision; 16; 17-8-2010; 1654-1658
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