Mostrar el registro sencillo del ítem

dc.contributor.author
Imperiale, Julieta Celeste  
dc.contributor.author
Sosnik, Alejandro Dario  
dc.date.available
2015-08-28T15:22:58Z  
dc.date.issued
2013-02  
dc.identifier.citation
Imperiale, Julieta Celeste; Sosnik, Alejandro Dario; Nanoparticle-in-Microparticle Delivery Systems (NiMDS): Production, Administration Routes and Clinical Potential; American Scientific Publishers; Journal of Biomaterials and Tissue Engineering; 3; 1; 2-2013; 22-38  
dc.identifier.issn
2157-9083  
dc.identifier.uri
http://hdl.handle.net/11336/1866  
dc.description.abstract
Microparticles (MPs) and nanoparticles (NPs) have received considerable attention for the design of drug delivery systems (DDS) with unique properties owing to the increased surface area and the ability to fine tune the release process. More recently, a new type of DDS that capitalize on the advantages of both NPs and MPs has been introduced. Nanoparticle-in-Microparticle Delivery Systems (NiMDS) comprise the encapsulation of NPs within MPs and lead to features that are unique and different from those of the individual components. These technology platforms can be produced employing from conventional to more sophisticated methodologies and equipment and they are administered by different routes such as oral, pulmonary or even parenteral. Moreover, if designed appropriately, they can (i) protect drug payloads and prevent physical and chemical instability phenomena in the biological environment, (ii) improve the release profile of the encapsulated agent, (iii) reduce or eliminate the burst effect and (iv) target specific cells, tissues and organs. The present review overviews the different approaches to produce NiMDS and discusses their potential implementation in clinics.  
dc.description.abstract
Microparticles (MPs) and nanoparticles (NPs) have received considerable attention for the design of drug delivery systems (DDS) with unique properties owing to the increased surface area and the ability to fine tune the release process. More recently, a new type of DDS that capitalize on the advantages of both NPs and MPs has been introduced. Nanoparticle-in-Microparticle Delivery Systems (NiMDS) comprise the encapsulation of NPs within MPs and lead to features that are unique and different from those of the individual components. These technology platforms can be produced employing from conventional to more sophisticated methodologies and equipment and they are administered by different routes such as oral, pulmonary or even parenteral. Moreover, if designed appropriately, “they can (i) protect drug payloads and prevent physical and chemical instability phenomena in the biological environment, (ii) improve the release profile of the encapsulated agent, (iii) reduce or eliminate the burst effect and (iv) target specific cells, tissues and organs.” Should be changed to “they can protect drug payloads and prevent physical and chemical instability phenomena in the biological environment, improve the release profile of the encapsulated agent, reduce or eliminate the burst effect and target specific cells, tissues and organs.”  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Scientific Publishers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Nanoparticle-In-Microparticle Delivery Systems  
dc.subject
Burst Effect Control  
dc.subject
Release Kinetics Fine Tuning  
dc.subject
Drug Targeting  
dc.subject.classification
Nano-materiales  
dc.subject.classification
Nanotecnología  
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Nanoparticle-in-Microparticle Delivery Systems (NiMDS): Production, Administration Routes and Clinical Potential  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-03-30 10:35:44.97925-03  
dc.identifier.eissn
2157-9091  
dc.journal.volume
3  
dc.journal.number
1  
dc.journal.pagination
22-38  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Valencia  
dc.description.fil
Fil: Imperiale, Julieta Celeste. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina; Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina;  
dc.description.fil
Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;  
dc.journal.title
Journal of Biomaterials and Tissue Engineering  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1166/jbt.2013.1064  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/asp/jbte/2013/00000003/00000001/art00003