Mostrar el registro sencillo del ítem

dc.contributor.author
Chiappetta, Diego Andrés  
dc.contributor.author
Hocht, Christian  
dc.contributor.author
Opezzo, Javier A. W.  
dc.contributor.author
Sosnik, Alejandro Dario  
dc.date.available
2015-08-28T15:22:13Z  
dc.date.issued
2012-11-22  
dc.identifier.citation
Chiappetta, Diego Andrés; Hocht, Christian; Opezzo, Javier A. W.; Sosnik, Alejandro Dario; Intranasal administration of antiretroviral-loaded micelles for anatomical targeting to the brain in HIV; Future Medicine; Nanomedicine; 8; 2; 22-11-2012; 223-237  
dc.identifier.issn
1743-5889  
dc.identifier.uri
http://hdl.handle.net/11336/1865  
dc.description.abstract
We investigated the intranasal administration of poly(ethylene oxide)–poly(propylene oxide) polymeric micelles loaded with high payloads of the first-line antiretroviral drug efavirenz for targeting to the CNS. The effect of micellar size and composition and drug payload was assessed, employing simple micelles made of a highly hydrophilic copolymer, poloxamer F127, loaded with 20 mg/ml drug and mixed micelles containing 75% of a medium hydrophobic poloxamine, T904, and 25% F127 loaded with 20 and 30 mg/ml drug, respectively. F127 confers high physical stability, while T904 substantially improves the encapsulation capacity of the micelles. The bioavailability of the drug in the CNS was increased fourfold and the relative exposure index (ratio between the area-under-the-curve in the CNS and plasma) was increased fivefold with respect to the same system administered intravenously. These findings demonstrate the potential of this scalable and cost-viable strategy to attack the HIV sanctuary in the CNS.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Future Medicine  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Anatomical Targeting To the Brain  
dc.subject
Cns  
dc.subject
Efavirenz-Loaded Micelles  
dc.subject
Hiv Reservoirs  
dc.subject.classification
Nano-materiales  
dc.subject.classification
Nanotecnología  
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS  
dc.subject.classification
Farmacología y Farmacia  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Intranasal administration of antiretroviral-loaded micelles for anatomical targeting to the brain in HIV  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-03-30 10:35:44.97925-03  
dc.journal.volume
8  
dc.journal.number
2  
dc.journal.pagination
223-237  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;  
dc.description.fil
Fil: Hocht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina;  
dc.description.fil
Fil: Opezzo, Javier A. W.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina;  
dc.description.fil
Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;  
dc.journal.title
Nanomedicine  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/DOI:10.2217/nnm.12.104  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.futuremedicine.com/doi/abs/10.2217/nnm.12.104?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&