Mostrar el registro sencillo del ítem
dc.contributor.author
Bernabeu, Ezequiel Adrian
dc.contributor.author
Chiappetta, Diego Andrés
dc.date.available
2015-08-28T15:21:00Z
dc.date.issued
2013-02
dc.identifier.citation
Bernabeu, Ezequiel Adrian; Chiappetta, Diego Andrés; Vitamin E TPGS Used as Emulsifier in the Preparation of Nanoparticulate Systems; American Scientific Publishers; Journal of Biomaterials and Tissue Engineering; 3; 1; 2-2013; 122-134
dc.identifier.issn
2157-9083
dc.identifier.uri
http://hdl.handle.net/11336/1864
dc.description.abstract
In recent years, nanoparticulate systems have matured from simple devices to multifunctional and more complex systems. They are biodegradable, stable in blood, non-toxic, and non immunogenic construct, capable of delivering drugs in a specific site, thereby improving efficacy. Their capabilities as drug delivery system and the interaction with the biological cells in the target tissue are dependent on their physicochemical properties such as particles size, size distribution, surface charge and morphology. Polymeric nanoparticles are usually produced by two classical methods: nanoprecipitation and emulsion-solvent evaporation technique. In such process, a number of preparation parameters can affect the nature of the nanoparticles as: drug, polymer concentration, temperature, solvent volume, aqueous:organic phase ratio, type and concentration of emulsifier and so forth. One of the most important formulation parameters involves the emulsifier, which is necessary as surfactant stabilizer in the process to form nanoparticles. D-α-tocopheryl polyethylene glycol (PEG) 1000 succinate (TPGS) is a water soluble derivate of natural source vitamin E. It is amphipathic and hydrophilic, exhibiting the characteristics of a typical surface-active agent. This review summarizes recently available information regarding the emulsifying effects of TPGS on the preparation, characterization, in vitro release and in vivo performance of the nanoparticulate systems, and the advantages of TPGS-drug conjugates.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Scientific Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Tpgs
dc.subject
Biodegradable Polymeric Nanoparticle
dc.subject
Vitamin e Tpgs
dc.subject
Tpgs-Drug Conjugates
dc.subject.classification
Nano-materiales
dc.subject.classification
Nanotecnología
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Vitamin E TPGS Used as Emulsifier in the Preparation of Nanoparticulate Systems
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
2157-9091
dc.journal.volume
3
dc.journal.number
1
dc.journal.pagination
122-134
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Valencia
dc.description.fil
Fil: Bernabeu, Ezequiel Adrian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina;
dc.description.fil
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
dc.journal.title
Journal of Biomaterials and Tissue Engineering
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1166/jbt.2013.1076
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/asp/jbte/2013/00000003/00000001/art00009
Archivos asociados