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dc.contributor.author
Boukari, Kahina
dc.contributor.author
Meduri, Geri
dc.contributor.author
Brailly Tabard, Sylvie
dc.contributor.author
Guibourdenche, Jean
dc.contributor.author
Ciampi, Maria Luisa
dc.contributor.author
Massin, Nathalie
dc.contributor.author
Martinerie, Laetitia
dc.contributor.author
Picard, Jean Yves
dc.contributor.author
Rey, Rodolfo Alberto
dc.contributor.author
Lombès, Marc
dc.contributor.author
Young, Jacques
dc.date.available
2023-01-31T17:31:01Z
dc.date.issued
2009-12
dc.identifier.citation
Boukari, Kahina; Meduri, Geri; Brailly Tabard, Sylvie; Guibourdenche, Jean; Ciampi, Maria Luisa; et al.; Lack of androgen receptor expression in Sertoli Cells accounts for the absence of Anti-Müllerian Hormone repression during early human testis development.; Endocrine Society; Journal of Clinical Endocrinology and Metabolism; 94; 5; 12-2009; 1818-1825
dc.identifier.issn
0021-972X
dc.identifier.uri
http://hdl.handle.net/11336/186321
dc.description.abstract
Context: Puberty is associated with increased testicular testosterone (TT) synthesis, which is required to trigger spermatogenesis and to repress anti-Mullerian hormone (AMH) production. However, testicular gonadotropin stimulation during fetal and newborn life neither initiates spermatogenesis nor represses AMH. Objective: We postulated that a lack of androgen receptor (AR) expression in Sertoli cells (SC) might explain why these processes do not occur during early human development. Methods and Patients: Using immunohistochemistry and quantitative PCR, we examined the relationship between AR, AMH, and FSH receptor expression in fetal, newborn, and adult human testis. The ability of testosterone to repress AMH secretion was evaluated in male newborns, neonates, and two adults with androgen insensitivity syndrome and also in vitro using SMAT1 SC. Results: FSH receptor was present in SC at all developmental stages. In fetal and newborn testis, AR was expressed in peritubular and Leydig cells but not in SC. This coincided with the absence of spermatogenesis and with strong SC AMH expression. In adult testis, spermatogenesis was associated with AR expression and with a decrease in SC AMH content. Accordingly, AR mRNA expression was lower and AMH mRNA expression higher in fetal testes than in adult testes. In androgen insensitivity syndrome patients, combined gonadotropin stimulation induced an increase in circulating testosterone and AMH, a finding consistent with a failure of TT to repress AMH in the absence of AR signalling. Finally, direct androgen repression of AMH only occurred in AR-expressing SMAT1 cells. Conclusion: Functional ARs are essential for TT-mediated AMH repression in SC.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Endocrine Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMH
dc.subject.classification
Endocrinología y Metabolismo
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Lack of androgen receptor expression in Sertoli Cells accounts for the absence of Anti-Müllerian Hormone repression during early human testis development.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-11T18:21:20Z
dc.journal.volume
94
dc.journal.number
5
dc.journal.pagination
1818-1825
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Boukari, Kahina. Inserm; Francia
dc.description.fil
Fil: Meduri, Geri. Inserm; Francia
dc.description.fil
Fil: Brailly Tabard, Sylvie. Inserm; Francia
dc.description.fil
Fil: Guibourdenche, Jean. Hôpital Robert Debré; Francia
dc.description.fil
Fil: Ciampi, Maria Luisa. Università degli Studi di Bari; Italia
dc.description.fil
Fil: Massin, Nathalie. Université Paris 12; Francia
dc.description.fil
Fil: Martinerie, Laetitia. Inserm; Francia
dc.description.fil
Fil: Picard, Jean Yves. Inserm; Francia
dc.description.fil
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
dc.description.fil
Fil: Lombès, Marc. Inserm; Francia
dc.description.fil
Fil: Young, Jacques. Inserm; Francia
dc.journal.title
Journal of Clinical Endocrinology and Metabolism
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jcem/article/94/5/1818/2598685?login=false
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1210/jc.2008-1909
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