Evento
Identification and annotation of plasmids in Next Generation Sequencing microbial genomic data
Tipo del evento:
Congreso
Nombre del evento:
Humboldt Colloquium "Shaping the Future of German-Argentinian Scientific Cooperation" The Role of Curiosity-Driven Research"
Fecha del evento:
10/2018
Institución Organizadora:
Alexander von Humboldt-Stiftung;
Título del Libro:
Networking guide
Editorial:
Conventus Congressmanagement & Marketing GmbH
Idioma:
Inglés
Clasificación temática:
Resumen
Plasmids are autoreplicative mobile elementsconstituted by asingle DNA molecule, which can be linear or circular. They are partof the genetic background of a microbial community and have thepotential to be transferred between different members. This isparticularly important in hospital settingswhere this mobility may contribute todissemination of antibiotic resistance encoded in the plasmids. Indifferent niches, plasmids could be a source of resistance to otherenvironmental factors.Withthe development of NGS techniques, plasmids have become less relevantamong the flood of data. Only recently algorithms have beendeveloped, allowing prediction of sequences belonging to plasmidsfrom short sequence NGS datasets. Public databases present aconstantly increasing number of such datasets. Thus, we aim to applycurrent plasmids detection methodologies to public data and build aplasmid database based on full well characterized plasmids but alsoincluding predictions.This would provide relevant data about the abilityto transfer genetic material of different strains, about geneticdeterminants of resistance (either to antibiotic or environmentalstress) encoded in mobile elements, and on the possibility of usingsome of these plasmids as new genetic tools for different microbialgenera, particularly in those where tools are not available.
Palabras clave:
SEQUENCING
,
PLASMID
,
GENOMICS
,
ENVIRONMENTAL MICROBIOLOGY
Archivos asociados
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Identificadores
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Eventos(PROIMI)
Eventos de PLANTA PILOTO DE PROC.IND.MICROBIOLOGICOS (I)
Eventos de PLANTA PILOTO DE PROC.IND.MICROBIOLOGICOS (I)
Citación
Identification and annotation of plasmids in Next Generation Sequencing microbial genomic data; Humboldt Colloquium "Shaping the Future of German-Argentinian Scientific Cooperation" The Role of Curiosity-Driven Research"; Buenos Aires, Argentina; Argentina; 2018
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