Structural and dynamic characterization of solid furosemide polymorphs by NQR and NMR methods

The temperature dependence of NQR parameters and proton spin-lattice relaxation times of furosemide in forms 1 and 2 are reported. The NQR line shape shows that form 2 is disordered, even at low temperatures and reorientation of the SO2NH2 group between conformers has been detected above 120 K. Through T1H measurements a transition of form 2 to the high temperature phase of furosemide is observed around 405 K. The high temperature phase is characterized by one NQR line indicating Z′ = 1 in this phase. Proton transfer and NH2 jumps in form 1 are also observed through T1Q measurements.

Palabras clave: 35 Cl NQR , FUROSEMIDE POLYMORPHS , DISORDER

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)

Identificadores

URI: http://hdl.handle.net/11336/186222

URL: http://www.sciencedirect.com/science/article/pii/S0009261415008295

DOI: http://dx.doi.org/10.1016/j.cplett.2015.10.066

Colecciones

Articulos(IFEG)
Articulos de INST.DE FISICA ENRIQUE GAVIOLA

Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA

Citación

Wolfenson, Alberto Enrique; Perez, Silvina Claudia; Zuriaga, Mariano Jose; Garnero, Claudia; Abraham Miranda, Julieta; et al.; Structural and dynamic characterization of solid furosemide polymorphs by NQR and NMR methods; Elsevier Science; Chemical Physics Letters; 641; 11-2015; 163-168

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