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dc.contributor.author
Alfei, Joaquín M.
dc.contributor.author
Ferrer Monti, Roque Ignacio
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Molina, Victor Alejandro
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De Bundel, Dimitri
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Luyten, Laura
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Beckers, Tom
dc.date.available
2023-01-30T18:33:15Z
dc.date.issued
2020-11
dc.identifier.citation
Alfei, Joaquín M.; Ferrer Monti, Roque Ignacio; Molina, Victor Alejandro; De Bundel, Dimitri; Luyten, Laura; et al.; Generalization and recovery of post-retrieval amnesia; American Psychological Association; Journal Of Experimental Psychology-general; 149; 11; 11-2020; 2063-2083
dc.identifier.issn
0096-3445
dc.identifier.uri
http://hdl.handle.net/11336/186177
dc.description.abstract
Selective amnesia for previously established memories can be induced by administering drugs that impair protein synthesis shortly after memory reactivation. Competing theoretical accounts attribute this selective post-retrieval amnesia to drug-induced engram degradation (reconsolidation blockade) or to incorporation of sensory features of the reactivation experience into the memory representation, hampering later retrieval in a drug-free state (memory integration). Here we present evidence that critically challenges both accounts. In contextual fear conditioning in rats, we find that amnesia induced by administration of midazolam (MDZ) after reexposure to the training context A generalizes readily to a similar context B. Amnesia is also observed when animals are exposed to the similar context B prior to MDZ administration and later tested for fear to context B but recovers when instead testing for fear to the original training context A or an equally similar but novel context C. Next to their theoretical implications for the nature of forgetting, our findings raise important questions about the viability of reconsolidation-based interventions for the treatment of emotional disorders. (PsycInfo Database Record (c) 2020 APA, all rights reserved)
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application/pdf
dc.language.iso
eng
dc.publisher
American Psychological Association
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GENERALIZATION
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MEMORY
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MIDAZOLAM
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POST-RETRIEVAL AMNESIA
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PREDICTION ERROR
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RECONSOLIDATION
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Generalization and recovery of post-retrieval amnesia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-01-30T15:30:26Z
dc.journal.volume
149
dc.journal.number
11
dc.journal.pagination
2063-2083
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Alfei, Joaquín M.. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Ferrer Monti, Roque Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Molina, Victor Alejandro. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
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Fil: De Bundel, Dimitri. Free Universities Of Brussels; Bélgica
dc.description.fil
Fil: Luyten, Laura. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Beckers, Tom. Katholikie Universiteit Leuven; Bélgica
dc.journal.title
Journal Of Experimental Psychology-general
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://psycnet.apa.org/doiLanding?doi=10.1037%2Fxge0000765
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1037/xge0000765
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