Artículo
Climatic droplet keratopathy: An old disease in new clothes
Serra, Horacio Marcelo
; Holopainen, Juha M.; Beuerman, Roger; Kaarniranta, Kai; Suarez, Maria Fernanda
; Urrets Zavalía, Julio Alberto
Fecha de publicación:
09/2015
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Acta Ophthalmologica
ISSN:
1755-375X
e-ISSN:
1755-3768
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Climatic droplet keratopathy (CDK) is an acquired and potentially handicapping cornea degenerative disease that is highly prevalent in certain rural communities around the world. It predominantly affects males over their forties. It has many other names such as Bietti's band-shaped nodular dystrophy, Labrador keratopathy, spheroidal degeneration, chronic actinic keratopathy, oil droplet degeneration, elastoid degeneration and keratinoid corneal degeneration. CDK is characterized by the haziness and opalescence of the cornea's most anterior layers which go through three stages with increasing severity. Globular deposits of different sizes may be histopathologically observed under the corneal epithelium by means of light and electron microscopy. The coalescence and increased volume of these spherules may cause the disruption of Bowman's membrane and the elevation and thinning of the corneal epithelium. The exact aetiology and pathogenesis of CDK are unknown, but they are possibly multifactorial. The only treatment in CDK advanced cases is a corneal transplantation, which in different impoverished regions of the world is not an available option. Many years ago, the clinical and histological aspects of this disease were described in several articles. This review highlights new scientific evidence of the expanding knowledge on CDK's pathogenesis which will open the prospect for new therapeutic interventions.
Palabras clave:
ASCORBATE
,
ENVIRONMENT
,
HUMAN
,
KERATOPATHY
,
UV-B
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Colecciones
Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Citación
Serra, Horacio Marcelo; Holopainen, Juha M.; Beuerman, Roger; Kaarniranta, Kai; Suarez, Maria Fernanda; et al.; Climatic droplet keratopathy: An old disease in new clothes; Wiley Blackwell Publishing, Inc; Acta Ophthalmologica; 93; 6; 9-2015; 496-504
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