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dc.contributor.author
Lipszyc, P.
dc.contributor.author
Cremaschi, Graciela Alicia
dc.contributor.author
Zorrilla Zubilete, María Aurelia
dc.contributor.author
Aon Bertolino, María Laura
dc.contributor.author
Capani, Francisco
dc.contributor.author
Genaro, Ana Maria
dc.contributor.author
Wald, Miriam Ruth
dc.date.available
2015-08-28T14:59:28Z
dc.date.issued
2013-09-20
dc.identifier.citation
Lipszyc, P.; Cremaschi, Graciela Alicia; Zorrilla Zubilete, María Aurelia; Aon Bertolino, María Laura; Capani, Francisco; et al.; Niacin modulates pro-inflammatory cytokine secretion. A potential mechanism involved in its anti-atherosclerotic effect; Betham; Open Cardiovascular Medicine Journal; 7; 20-9-2013; 90-98
dc.identifier.issn
1874-1924
dc.identifier.uri
http://hdl.handle.net/11336/1858
dc.description.abstract
The pathogenesis of atherosclerosis includes the assignment of a critical role to cells of the monocyte/macrophage lineage and to pro-inflammatory cytokines. Niacin is known to improve lipid metabolism and to produce beneficial modification of cardiovascular risk factors. The aim of this work was to investigate if Niacin is able to modulate pro-inflammatory cytokine production in macrophages in a murine model of atherosclerosis. For this purpose C57Bl/6J mice fed with atherogenic diet (AGD) or with conventional chow diet were used. The AGD group showed an increase in body weight and in total plasma cholesterol, with no differences in triglyceride or HDL levels. Lesions in arterial walls were observed. The characterization of Niacin receptor showed an increase in the receptor number of macrophages from the AGD group. Macrophages from control and AGD animals treated in vitro with an inflammatory stimulus showed elevated levels of IL-6, IL-1 and TNF-α, that were even higher in macrophages from AGD mice. Niacin was able to decrease the production of pro-inflammatory cytokines in stimulated macrophages. Similar effect of Niacin was observed in an in vivo model of inflammation. These results show an attenuating inflammatory mechanism for this therapeutic agent and would point out its potential action in plaque stabilization and in the prevention of atherosclerosis progression. Furthermore, the present results provide the basis for future studies on the potential contribution of Niacin to antiinflammatory therapies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Betham
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nicotinic Acid Receptor
dc.subject
Atherosclerosis
dc.subject
Inflammation
dc.subject
Niacin
dc.subject
Macrophages
dc.subject
Pro-Inflammatory Cytokine
dc.subject.classification
Farmacología y Farmacia
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Niacin modulates pro-inflammatory cytokine secretion. A potential mechanism involved in its anti-atherosclerotic effect
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
7
dc.journal.pagination
90-98
dc.journal.pais
Emiratos Arabes Unidos
dc.journal.ciudad
Sharjah
dc.description.fil
Fil: Lipszyc, P.. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina;
dc.description.fil
Fil: Cremaschi, Graciela Alicia. Pontificia Universidad Católica Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
dc.description.fil
Fil: Zorrilla Zubilete, María Aurelia. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina;
dc.description.fil
Fil: Aon Bertolino, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina;
dc.description.fil
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina;
dc.description.fil
Fil: Genaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina;
dc.description.fil
Fil: Wald, Miriam Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina;
dc.journal.title
Open Cardiovascular Medicine Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://benthamopen.com/contents/pdf/TOCMJ/TOCMJ-7-90.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805984/pdf/TOCMJ-7-90.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.2174/1874192401307010090
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