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dc.contributor.author
Coll Bonfill, Núria
dc.contributor.author
Musri, Melina Mara
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dc.contributor.author
Ivo, Victor
dc.contributor.author
Barberà, Joan Albert
dc.contributor.author
Tura Ceide, Olga
dc.date.available
2023-01-27T12:54:18Z
dc.date.issued
2015-03
dc.identifier.citation
Coll Bonfill, Núria; Musri, Melina Mara; Ivo, Victor; Barberà, Joan Albert; Tura Ceide, Olga; Transdifferentiation of endothelial cells to smooth muscle cells play an important role in vascular remodelling; e-Century Publishing Corporation; American Journal of Stem Cells; 4; 1; 3-2015; 13-21
dc.identifier.issn
2160-4150
dc.identifier.uri
http://hdl.handle.net/11336/185887
dc.description.abstract
Pulmonary artery remodelling it is a major feature of pulmonary hypertension (PH). It is characterised by cellular and structural changes of the pulmonary arteries causing higher pulmonar vascular resistance and right ventricular failure. Abnormal deposition of smooth muscle-like (SM-like) cells in normally non-muscular, small diameter vessels and a deregulated control of endothelial cells are considered pathological features of PH. The origin of the SM-like cells and the mechanisms underlying the development and progression of this remodelling process are not understood. Endothelial cells within the intima may migrate from their organised layer of cells and transition to mesenchymal or SM-like phenotype in a process called endothelial-mesenchymal transition (EnMT). Traditionally, Waddington’s epigenetic landscape illustrates that fates of somatic cells are progressively determined to compulsorily follow a downhill differentiation pathway. EnMT induces the transformation of cells with stem cell traits, therefore contrasting Waddington’s theory and confirming that cell fate seems to be far more flexible than previously thought. The prospect of therapeutic inhibition of EnMT to delay or prevent PH may represent a promising new treatment modality.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
e-Century Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ENDOTHELIAL TO MESENCHYMAL TRANSITION
dc.subject
ENDOTHELIAL CELLS
dc.subject
SMOOTH MUSCLE CELLS
dc.subject
VASCULAR REMODELING
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Transdifferentiation of endothelial cells to smooth muscle cells play an important role in vascular remodelling
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-01-23T16:41:44Z
dc.journal.volume
4
dc.journal.number
1
dc.journal.pagination
13-21
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Madison
dc.description.fil
Fil: Coll Bonfill, Núria. Universidad de Barcelona; España
dc.description.fil
Fil: Musri, Melina Mara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad de Barcelona; España
dc.description.fil
Fil: Ivo, Victor. Universidad de Barcelona; España. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias; España
dc.description.fil
Fil: Barberà, Joan Albert. Universidad de Barcelona; España. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias; España
dc.description.fil
Fil: Tura Ceide, Olga. Universidad de Barcelona; España. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias; España
dc.journal.title
American Journal of Stem Cells
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ajsc.us/V4_No1.html
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