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dc.contributor.author
Pereira, Rafael Nicolay
dc.contributor.author
Fandaruff, Cinira
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dc.contributor.author
Riekes, Manoela Klüppel
dc.contributor.author
Monti, Gustavo Alberto
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dc.contributor.author
De Campos, Carlos Eduardo Maduro
dc.contributor.author
Cuffini, Silvia Lucia
dc.contributor.author
Silva, Marcos Antonio Segatto
dc.date.available
2023-01-26T19:03:53Z
dc.date.issued
2015-02
dc.identifier.citation
Pereira, Rafael Nicolay; Fandaruff, Cinira; Riekes, Manoela Klüppel; Monti, Gustavo Alberto; De Campos, Carlos Eduardo Maduro; et al.; Grinding effect on levofloxacin hemihydrate; Springer; Journal of Thermal Analysis and Calorimetry; 119; 2; 2-2015; 989-994
dc.identifier.issn
1388-6150
dc.identifier.uri
http://hdl.handle.net/11336/185833
dc.description.abstract
The grinding techniques were used in different pharmacotechnical process. The control of the effect of grinding in solid state properties of drugs is very important, mainly in hydrated drugs. Levofloxacin hemihydrate (LVF) is a good example of this type of compounds and a broad spectrum antibiotic of the fluoroquinolone drug class. The samples of LVF with and without grinding were studied using different characterization techniques such as thermogravimetry, differential scanning calorimetry, fourier-transformed infrared, X-ray powder diffraction, and hot stage microscopy. The purpose of the present study was to evaluate the effects of grinding in the dehydration and rehydration processes in levofloxacin hemihydrate. After heating, the samples lost water molecules and the rehydration process was modified depending on defects due to the grinding. At room temperature, the complete transformation to the hemihydrate form was detected only for the sample without grinding. On the other hand, the milled sample showed two phases, hydrate and anhydrate forms. Therefore, the defects in the crystalline structure would cause the irreversible transformation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GRINDING
dc.subject
HEMIHYDRATE
dc.subject
LEVOFLOXACIN
dc.subject
REHYDRATION
dc.subject.classification
Química Orgánica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Grinding effect on levofloxacin hemihydrate
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-01-23T16:42:01Z
dc.identifier.eissn
1588-2926
dc.journal.volume
119
dc.journal.number
2
dc.journal.pagination
989-994
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlín
dc.description.fil
Fil: Pereira, Rafael Nicolay. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Fandaruff, Cinira. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Riekes, Manoela Klüppel. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
dc.description.fil
Fil: De Campos, Carlos Eduardo Maduro. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Cuffini, Silvia Lucia. Universidade Federal de Sao Paulo; Brasil. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Silva, Marcos Antonio Segatto. Universidade Federal de Santa Catarina; Brasil
dc.journal.title
Journal of Thermal Analysis and Calorimetry
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10973-014-4233-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10973-014-4233-1
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