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dc.contributor.author
Canton, Johnathan
dc.contributor.author
Blees, Hanna
dc.contributor.author
Henry, Conor M.
dc.contributor.author
Buck, Michael D.
dc.contributor.author
Schulz, Oliver
dc.contributor.author
Rogers, Neil C.
dc.contributor.author
Childs, Eleanor
dc.contributor.author
Zelenay, Santiago
dc.contributor.author
Rhys, Hefin
dc.contributor.author
Domart, Marie Charlotte
dc.contributor.author
Collinson, Lucy
dc.contributor.author
Alloatti, Andrés
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dc.contributor.author
Ellison, Cara J.
dc.contributor.author
Amigorena, Sebastian
dc.contributor.author
Papayannopoulos, Venizelos
dc.contributor.author
Thomas, David C.
dc.contributor.author
Randow, Felix
dc.contributor.author
Reis e Sousa, Caetano
dc.date.available
2023-01-26T13:45:56Z
dc.date.issued
2021-02
dc.identifier.citation
Canton, Johnathan; Blees, Hanna; Henry, Conor M.; Buck, Michael D.; Schulz, Oliver; et al.; The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens; Nature Publishing Group; Nature Immunology (print); 22; 2; 2-2021; 140-153
dc.identifier.issn
1529-2908
dc.identifier.uri
http://hdl.handle.net/11336/185763
dc.description.abstract
Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8+ T cells. cDC1 cells can be identified in mice and humans by high expression of DNGR-1 (also known as CLEC9A), a receptor that binds dead-cell debris and facilitates XP of corpse-associated antigens. Here, we show that DNGR-1 is a dedicated XP receptor that signals upon ligand engagement to promote phagosomal rupture. This allows escape of phagosomal contents into the cytosol, where they access the endogenous major histocompatibility complex class I antigen processing pathway. The activity of DNGR-1 maps to its signaling domain, which activates SYK and NADPH oxidase to cause phagosomal damage even when spliced into a heterologous receptor and expressed in heterologous cells. Our data reveal the existence of innate immune receptors that couple ligand binding to endocytic vesicle damage to permit MHC class I antigen presentation of exogenous antigens and to regulate adaptive immunity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DNRG-1
dc.subject
dendritic cells
dc.subject
cross-presentation
dc.subject
phagosome rupture
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-10-06T10:42:49Z
dc.journal.volume
22
dc.journal.number
2
dc.journal.pagination
140-153
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Canton, Johnathan. No especifíca;
dc.description.fil
Fil: Blees, Hanna. No especifíca;
dc.description.fil
Fil: Henry, Conor M.. No especifíca;
dc.description.fil
Fil: Buck, Michael D.. The Francis Crick Institute; Reino Unido
dc.description.fil
Fil: Schulz, Oliver. The Francis Crick Institute; Reino Unido
dc.description.fil
Fil: Rogers, Neil C.. The Francis Crick Institute; Reino Unido
dc.description.fil
Fil: Childs, Eleanor. The Francis Crick Institute; Reino Unido
dc.description.fil
Fil: Zelenay, Santiago. University of Manchester; Reino Unido
dc.description.fil
Fil: Rhys, Hefin. No especifíca;
dc.description.fil
Fil: Domart, Marie Charlotte. The Francis Crick Institute; Reino Unido
dc.description.fil
Fil: Collinson, Lucy. The Francis Crick Institute; Reino Unido
dc.description.fil
Fil: Alloatti, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
dc.description.fil
Fil: Ellison, Cara J.. Imperial College London; Reino Unido
dc.description.fil
Fil: Amigorena, Sebastian. Inserm; Francia
dc.description.fil
Fil: Papayannopoulos, Venizelos. The Francis Crick Institute; Reino Unido
dc.description.fil
Fil: Thomas, David C.. University of Cambridge; Estados Unidos
dc.description.fil
Fil: Randow, Felix. Imperial College London; Reino Unido
dc.description.fil
Fil: Reis e Sousa, Caetano. The Francis Crick Institute; Reino Unido
dc.journal.title
Nature Immunology (print)
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41590-020-00824-x
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