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dc.contributor.author
Cedron, Vanessa P.
dc.contributor.author
Weiner, Andrea Maria Julia
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dc.contributor.author
Vera, Manuel
dc.contributor.author
Sanchez, Laura
dc.date.available
2023-01-26T13:30:09Z
dc.date.issued
2020-04
dc.identifier.citation
Cedron, Vanessa P.; Weiner, Andrea Maria Julia; Vera, Manuel; Sanchez, Laura; Acetaminophen affects the survivor, pigmentation and development of craniofacial structures in zebrafish (Danio rerio) embryos; Pergamon-Elsevier Science Ltd; Biochemical Pharmacology; 174; 4-2020; 1-29
dc.identifier.issn
0006-2952
dc.identifier.uri
http://hdl.handle.net/11336/185752
dc.description.abstract
In spite of its toxic effects, N-acetyl-p-aminophenol (APAP), also commonly known as acetaminophen or paracetamol, is one of the most widely used analgesic and antipyretic agents. It can be obtained without a medical prescription. To test the effect over the zebrafish embryonic development, a Fish Embryo acute Toxicity (FET) test was carried out with acetaminophen to establish the range of concentrations that cause a harmful effect on the zebrafish development. Diminished pigmentation (in embryos treated from 0 h post-fertilization) and blockage of melanin synthesis (in larvae treated from 72 h post-fertilization) were detected, suggesting the involvement of this compound in the development of black pigment cells as described recently for human epidermal melanocytes. Morphological abnormalities such as aberrant craniofacial structures, pericardial edemas, and blood accumulation were also found. All these effects could be due to higher levels of apoptotic cells detected in treated embryos. Therefore, teratogenic effects of acetaminophen cannot be ruled out, and its wide use should be taken with caution.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ACETAMINOPHEN
dc.subject
DEPIGMENTATION
dc.subject
EMBRYONIC DEVELOPMENT
dc.subject
MORPHOLOGICAL ABNORMALITIES
dc.subject
TOXICITY TEST
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Acetaminophen affects the survivor, pigmentation and development of craniofacial structures in zebrafish (Danio rerio) embryos
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T21:06:57Z
dc.journal.volume
174
dc.journal.pagination
1-29
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Cedron, Vanessa P.. Universidad de Santiago de Compostela. Facultad de Veterinaria.; España
dc.description.fil
Fil: Weiner, Andrea Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Vera, Manuel. Universidad de Santiago de Compostela. Facultad de Veterinaria.; España
dc.description.fil
Fil: Sanchez, Laura. Universidad de Santiago de Compostela. Facultad de Veterinaria.; España
dc.journal.title
Biochemical Pharmacology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0006295220300265
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bcp.2020.113816
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