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dc.contributor.author
Menchón, Silvia Adriana
dc.date.available
2023-01-26T12:53:06Z
dc.date.issued
2015-06
dc.identifier.citation
Menchón, Silvia Adriana; The Effect of Intrinsic and Acquired Resistances on Chemotherapy Effectiveness; Springer; Acta Biotheoretica; 63; 2; 6-2015; 113-127
dc.identifier.issn
0001-5342
dc.identifier.uri
http://hdl.handle.net/11336/185722
dc.description.abstract
Although chemotherapy is one of the most common treatments for cancer, it can be only partially successful. Drug resistance is the main cause of the failure of chemotherapy. In this work, we present a mathematical model to study the impact of both intrinsic (preexisting) and acquired (induced by the drugs) resistances on chemotherapy effectiveness. Our simulations show that intrinsic resistance could be as dangerous as acquired resistance. In particular, our simulations suggest that tumors composed by even a small fraction of intrinsically resistant cells may lead to an unsuccessful therapy very quickly. Our results emphasize the importance of monitoring both intrinsic and acquired resistances during treatment in order to succeed and the importance of doing more experimental and genetic research in order to develop a pretreatment clinical test to avoid intrinsic resistance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACQUIRED RESISTANCE
dc.subject
CHEMOTHERAPY
dc.subject
INTRINSIC RESISTANCE
dc.subject
MATHEMATICAL MODELING AND SIMULATIONS
dc.subject.classification
Otras Ciencias Físicas
dc.subject.classification
Ciencias Físicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
The Effect of Intrinsic and Acquired Resistances on Chemotherapy Effectiveness
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-01-23T16:42:05Z
dc.identifier.eissn
1572-8358
dc.journal.volume
63
dc.journal.number
2
dc.journal.pagination
113-127
dc.journal.pais
Alemania
dc.journal.ciudad
Dordrecht
dc.description.fil
Fil: Menchón, Silvia Adriana. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
dc.journal.title
Acta Biotheoretica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s10441-015-9248-x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s10441-015-9248-x
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