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dc.contributor.author
Rodríguez Fdez, Sonia
dc.contributor.author
Lorenzo Martín, L. Francisco
dc.contributor.author
Fabbiano, Salvatore
dc.contributor.author
Menacho Márquez, Mauricio Ariel
dc.contributor.author
Vincent Sauzeau
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Dosil, Mercedes
dc.contributor.author
Bustelo, Xosé R.
dc.date.available
2023-01-25T17:21:33Z
dc.date.issued
2021-09
dc.identifier.citation
Rodríguez Fdez, Sonia; Lorenzo Martín, L. Francisco; Fabbiano, Salvatore; Menacho Márquez, Mauricio Ariel; Vincent Sauzeau; et al.; New functions of vav family proteins in cardiovascular biology, skeletal muscle, and the nervous system; MDPI; Biology; 10; 9; 9-2021; 1-14
dc.identifier.issn
2079-7737
dc.identifier.uri
http://hdl.handle.net/11336/185572
dc.description.abstract
Vav proteins act as tyrosine phosphorylation-regulated guanosine nucleotide exchange factors for Rho GTPases and as molecular scaffolds. In mammals, this family of signaling proteins is composed of three members (Vav1, Vav2, Vav3) that work downstream of protein tyrosine kinases in a wide variety of cellular processes. Recent work with genetically modified mouse models has revealed that these proteins play key signaling roles in vascular smooth and skeletal muscle cells, specific neuronal subtypes, and glia cells. These functions, in turn, ensure the proper regulation of blood pressure levels, skeletal muscle mass, axonal wiring, and fiber myelination events as well as systemic metabolic balance. The study of these mice has also led to the discovery of new physiological interconnection among tissues that contribute to the ontogeny and progression of different pathologies such as, for example, hypertension, cardiovascular disease, and metabolic syndrome. Here, we provide an integrated view of all these new Vav family-dependent signaling and physiological functions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
AXON WIRING
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BLOOD PRESSURE
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CYTOSKELETON
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GLIA
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HYPERTENSION
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METABOLIC SYNDROME
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MYELINATION
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NEURONS
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NITRIC OXIDE
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OBESITY
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PROTEIN TYROSINE KINASES
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RECEPTOR INTERNALIZATION
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SIGNALING
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SKELETAL MUSCLE CELLS
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SYMPATHETIC NERVOUS SYSTEM
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TYPE II DIABETES
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VASCULAR SMOOTH MUSCLE CELLS
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VASOCONSTRICTION
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VASODILATION
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VENTROLATERAL MEDULLA
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
New functions of vav family proteins in cardiovascular biology, skeletal muscle, and the nervous system
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-10-06T10:41:43Z
dc.journal.volume
10
dc.journal.number
9
dc.journal.pagination
1-14
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Rodríguez Fdez, Sonia. Universidad de Salamanca; España
dc.description.fil
Fil: Lorenzo Martín, L. Francisco. Universidad de Salamanca; España
dc.description.fil
Fil: Fabbiano, Salvatore. Universidad de Salamanca; España
dc.description.fil
Fil: Menacho Márquez, Mauricio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
dc.description.fil
Fil: Vincent Sauzeau. Universidad de Salamanca; España. Universite de Nantes; Francia
dc.description.fil
Fil: Dosil, Mercedes. Universidad de Salamanca; España
dc.description.fil
Fil: Bustelo, Xosé R.. Universidad de Salamanca; España
dc.journal.title
Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/biology10090857
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