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dc.contributor.author
Udovin, Lucas
dc.contributor.author
Aguilar, Andrea Pamela
dc.contributor.author
Kobiec, Tamara
dc.contributor.author
Herrera, María Inés
dc.contributor.author
Perez Lloret, Santiago
dc.contributor.author
Toro Urrego, Nicolas
dc.contributor.author
Kölliker Frers, Rodolfo A.
dc.contributor.other
Otero losada, Matilde Estela
dc.date.available
2023-01-25T10:19:55Z
dc.date.issued
2021
dc.identifier.citation
Udovin, Lucas; Aguilar, Andrea Pamela; Kobiec, Tamara; Herrera, María Inés; Perez Lloret, Santiago; et al.; Neuroprotective Properties of Cannabinoids in Cellular and Animal Models: Hypotheses and Facts; IntechOpen; 2021; 1-114
dc.identifier.isbn
978-1-83880-440-4
dc.identifier.uri
http://hdl.handle.net/11336/185484
dc.description.abstract
Progressive neuronal loss is a typical characteristic of neurodegenerative diseases.In Parkinson's disease, the loss of dopaminergic neurons in the basal ganglia resultsin impaired mobility and flawed muscle control. The loss of cholinergic neuronslargely in the basal forebrain contributes to memory and attention deficits and theoverall cognitive impairment in Alzheimer's disease. This being said, neuroprotec-tive drugs should be expected to preserve and/or restore the functions affected byneuronal loss, and substantially prevent cell death. The endocannabinoid system,comprising lipid mediators able to bind to and activate cannabinoid receptors,has emerged as a therapeutic target of potential interest in a variety of centralnervous system diseases. Palmitoylethanolamide (PEA) is one of the most impor-tant endocannabinoids, which has a key role in modulating oxidative stress andinflammatory response with neuroprotective potential in neurological disorders.Neurodegenerative diseases undergo varied, progressive stages. The current thera-peutical approaches are beginning to fall short when it comes to meet the expectedresults, urging to either develop or identify or develop new effective treatments. Thischapter discusses the neuroprotective potential of new drugs, aiming to shed somelight on their proposed mechanism of action and their effect in cellular and animalmodels of neurodegeneration.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
IntechOpen
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Parkinson?s disease
dc.subject
Alzheimer?s disease
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Endocannabinoid
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Palmitoylethanolamide (PEA)
dc.subject.classification
Otros Tópicos Biológicos
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Neuroprotective Properties of Cannabinoids in Cellular and Animal Models: Hypotheses and Facts
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2022-09-21T14:15:08Z
dc.journal.pagination
1-114
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Udovin, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Abierta Interamericana; Argentina
dc.description.fil
Fil: Aguilar, Andrea Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Kobiec, Tamara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
dc.description.fil
Fil: Herrera, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
dc.description.fil
Fil: Perez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Kölliker Frers, Rodolfo A.. No especifíca;
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/books/neuroprotection-new-approaches-and-prospects/neuroprotective-properties-of-cannabinoids-in-cellular-and-animal-models-hypotheses-and-facts
dc.conicet.paginas
500
dc.source.titulo
Neuroprotection: New approaches and prospect
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