Mostrar el registro sencillo del ítem
dc.contributor.author
Merola, Aristide
dc.contributor.author
Romagnolo, Alberto
dc.contributor.author
Dwivedi, Alok K.
dc.contributor.author
Padovani, Alessandro
dc.contributor.author
Berg, Daniela
dc.contributor.author
Garcia-Ruiz, Pedro J.
dc.contributor.author
Fabbri, Margherita
dc.contributor.author
Artusi, Carlo Alberto
dc.contributor.author
Zibetti, Maurizio
dc.contributor.author
Lopiano, Leonardo
dc.contributor.author
Pilotto, Andrea
dc.contributor.author
Bonacina, Sonia
dc.contributor.author
Morgante, Francesca
dc.contributor.author
Zeuner, Kirsten
dc.contributor.author
Griewing, Christopher
dc.contributor.author
Schaeffer, Eva
dc.contributor.author
Rodriguez-Porcel, Federico
dc.contributor.author
Kauffman, Marcelo Andres
dc.contributor.author
Mastroiacovo, Pierpaolo
dc.contributor.author
de Oliveira, Lais M.
dc.contributor.author
Palermo, Giovanni
dc.contributor.author
Shanks, Emily
dc.contributor.author
Del Sorbo, Francesca
dc.contributor.author
Bonvegna, Salvatore
dc.contributor.author
Savica, Rodolfo
dc.contributor.author
Munhoz, Renato P.
dc.contributor.author
Ceravolo, Roberto
dc.contributor.author
Cilia, Roberto
dc.contributor.author
Espay, Alberto J.
dc.date.available
2023-01-24T17:49:46Z
dc.date.issued
2020-10
dc.identifier.citation
Merola, Aristide; Romagnolo, Alberto; Dwivedi, Alok K.; Padovani, Alessandro; Berg, Daniela; et al.; Benign versus malignant Parkinson disease: the unexpected silver lining of motor complications; Dr. Dietrich Steinkopff Verlag; Journal of Neurology; 267; 10; 10-2020; 2949-2960
dc.identifier.issn
0340-5354
dc.identifier.uri
http://hdl.handle.net/11336/185452
dc.description.abstract
Objective: We sought to evaluate demographic, clinical, and habits/occupational variables between phenotypic extremes in Parkinson’s disease (PD). Methods: Databases from nine movement disorders centers across seven countries were retrospectively searched for subjects meeting criteria for very slowly progressive, benign, PD (bPD) and rapidly progressive, malignant, PD (mPD). bPD was defined as Hoehn and Yahr (H&Y) stage ≤ 3, normal cognitive function, and Schwab and England (S&E) score ≥ 70 after ≥ 20 years of PD (≥ 10 years if older than 60 at PD onset); mPD as H&Y > 3, S&E score < 70, and cognitive impairment within 10 years from PD onset. We performed between-group analysis of demographic, habits/occupational, and clinical features at baseline and follow-up and unsupervised data-driven analysis of the clinical homogeneity of bPD and mPD. Results: At onset, bPD subjects (n = 210) were younger, had a single limb affected, lower severity and greater asymmetry of symptoms, and lower prevalence of depression than mPD (n = 155). bPD was associated with active smoking and physical activity, mPD with agricultural occupation. At follow-up, mPD showed higher prevalence of depression, hallucinations, dysautonomia, and REM behaviour disorder. Interestingly, the odds of mPD were significantly reduced by the presence of dyskinesia and wearing-off. Data-driven analysis confirmed the independent clustering of bPD and mPD, with age at onset emerging as a critical discriminant between the two groups (< 46-year-old vs. > 68-year-old). Conclusions: Phenotypic PD extremes showed distinct demographic, clinical, and habits/occupational factors. Motor complications may be conceived as markers of therapeutic success given their attenuating effects on the odds of mPD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Dr. Dietrich Steinkopff Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AGING
dc.subject
BENIGN
dc.subject
EPIDEMIOLOGY
dc.subject
MALIGNANT
dc.subject
MOTOR COMPLICATIONS
dc.subject
PARKINSON
dc.subject.classification
Neurología Clínica
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Benign versus malignant Parkinson disease: the unexpected silver lining of motor complications
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T15:14:33Z
dc.journal.volume
267
dc.journal.number
10
dc.journal.pagination
2949-2960
dc.journal.pais
Alemania
dc.description.fil
Fil: Merola, Aristide. The Ohio State University Wexner Medical Center; Estados Unidos
dc.description.fil
Fil: Romagnolo, Alberto. Università di Torino; Italia
dc.description.fil
Fil: Dwivedi, Alok K.. Texas Tech University Health Sciences Center El Paso; Estados Unidos
dc.description.fil
Fil: Padovani, Alessandro. Università Degli Studi Di Brescia; Italia
dc.description.fil
Fil: Berg, Daniela. No especifíca;
dc.description.fil
Fil: Garcia-Ruiz, Pedro J.. Universidad Autónoma de Madrid; España
dc.description.fil
Fil: Fabbri, Margherita. Università di Torino; Italia. Universidade Nova de Lisboa; Portugal
dc.description.fil
Fil: Artusi, Carlo Alberto. Università di Torino; Italia
dc.description.fil
Fil: Zibetti, Maurizio. Università di Torino; Italia
dc.description.fil
Fil: Lopiano, Leonardo. Università di Torino; Italia
dc.description.fil
Fil: Pilotto, Andrea. Università Degli Studi Di Brescia; Italia
dc.description.fil
Fil: Bonacina, Sonia. Università Degli Studi Di Brescia; Italia
dc.description.fil
Fil: Morgante, Francesca. University of London; Reino Unido
dc.description.fil
Fil: Zeuner, Kirsten. No especifíca;
dc.description.fil
Fil: Griewing, Christopher. No especifíca;
dc.description.fil
Fil: Schaeffer, Eva. No especifíca;
dc.description.fil
Fil: Rodriguez-Porcel, Federico. No especifíca;
dc.description.fil
Fil: Kauffman, Marcelo Andres. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
dc.description.fil
Fil: Mastroiacovo, Pierpaolo. Università Degli Studi Di Brescia; Italia
dc.description.fil
Fil: de Oliveira, Lais M.. Toronto Western Hospital University Of Toronto; Canadá
dc.description.fil
Fil: Palermo, Giovanni. Università degli Studi di Pisa; Italia
dc.description.fil
Fil: Shanks, Emily. University of Cincinnati; Estados Unidos
dc.description.fil
Fil: Del Sorbo, Francesca. No especifíca;
dc.description.fil
Fil: Bonvegna, Salvatore. No especifíca;
dc.description.fil
Fil: Savica, Rodolfo. No especifíca;
dc.description.fil
Fil: Munhoz, Renato P.. Krembil Research Institute; Canadá
dc.description.fil
Fil: Ceravolo, Roberto. Università degli Studi di Pisa; Italia
dc.description.fil
Fil: Cilia, Roberto. No especifíca;
dc.description.fil
Fil: Espay, Alberto J.. University of Cincinnati; Estados Unidos
dc.journal.title
Journal of Neurology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00415-020-09954-6
Archivos asociados