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dc.contributor.author
Perone, Marcelo Javier  
dc.contributor.author
Windeatt, Simon  
dc.contributor.author
Castro, Maria G.  
dc.date.available
2023-01-24T17:45:25Z  
dc.date.issued
1997-07  
dc.identifier.citation
Perone, Marcelo Javier; Windeatt, Simon; Castro, Maria G.; Intracellular trafficking of prohormones and proneuropeptides: Cell type-specific sorting and targeting; Wiley Blackwell Publishing, Inc; Experimental Physiology; 82; 4; 7-1997; 609-628  
dc.identifier.uri
http://hdl.handle.net/11336/185442  
dc.description.abstract
Hormones and neuropeptides are usually synthesized as large precursor molecules which must undergo a series of post-translational modifications before they are released from secretory vesicles after stimulation by specific secretagogues. The classical vectorial transport of precursors and mature peptide products from the endoplasmic reticulum (ER) to their site of release has been the subject of intensive studies during the past 25 years, but there are a number of unresolved issues which still challenge cell biologists. The main issues are: (i) the molecular mechanisms underlying targeting and sorting of prohormones within the eukaryotic secretory pathway; (ii) further identification and intracellular site of action of post-translational processing enzymes; (iii) tissue-specific processing of hormone and neuropeptide precursors; and (iv) molecular mechanisms underlying intracellular transport ofl hormone and neuropeptide precursors and their cleavage products to alternative intracellular compartments besides the secretory pathway.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
PROHORMONE  
dc.subject
PROCESSING  
dc.subject
CRH  
dc.subject
POMC  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Intracellular trafficking of prohormones and proneuropeptides: Cell type-specific sorting and targeting  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-11-20T18:10:05Z  
dc.identifier.eissn
1469-445X  
dc.journal.volume
82  
dc.journal.number
4  
dc.journal.pagination
609-628  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Perone, Marcelo Javier. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina. University of Manchester; Reino Unido  
dc.description.fil
Fil: Windeatt, Simon. University of Manchester; Reino Unido  
dc.description.fil
Fil: Castro, Maria G.. University of Manchester; Reino Unido  
dc.journal.title
Experimental Physiology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/10.1113/expphysiol.1997.sp004051  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1113/expphysiol.1997.sp004051