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dc.contributor.author
Huang, Ying
dc.contributor.author
Sicar, Sanchari
dc.contributor.author
Ramirez Prado, Juan S.
dc.contributor.author
Manza Mianza, Deborah
dc.contributor.author
Antunez Sanchez, Javier
dc.contributor.author
Brik Chaouche, Rim
dc.contributor.author
Rodriguez Granados, Natalia Y.
dc.contributor.author
An, Jing
dc.contributor.author
Bergounioux, Catherine
dc.contributor.author
Mahfouz, Magdy M.
dc.contributor.author
Hirt, Heribert
dc.contributor.author
Crespi, Martin
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dc.contributor.author
Concia, Lorenzo
dc.contributor.author
Barneche, Fredy
dc.contributor.author
Amiard, Simon
dc.contributor.author
Probst, Aline V.
dc.contributor.author
Gutierrez Marcos, Jose
dc.contributor.author
Ariel, Federico Damian
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dc.contributor.author
Raynaud, Cécile
dc.contributor.author
Latrasse, David
dc.contributor.author
Benhamed, Moussa
dc.date.available
2023-01-23T13:08:16Z
dc.date.issued
2021-07
dc.identifier.citation
Huang, Ying; Sicar, Sanchari; Ramirez Prado, Juan S.; Manza Mianza, Deborah; Antunez Sanchez, Javier; et al.; Polycomb-dependent differential chromatin compartmentalization determines gene coregulation in Arabidopsis; Cold Spring Harbor Laboratory Press; Genome Research; 31; 7; 7-2021; 1230-1244
dc.identifier.issn
1088-9051
dc.identifier.uri
http://hdl.handle.net/11336/185238
dc.description.abstract
In animals, distant H3K27me3-marked Polycomb targets can establish physical interactions forming repressive chromatin hubs. In plants, growing evidence suggests that H3K27me3 acts directly or indirectly to regulate chromatin interactions, although how this histone modification modulates 3D chromatin architecture remains elusive. To decipher the impact of the dynamic deposition of H3K27me3 on the Arabidopsis thaliana nuclear interactome, we combined genetics, transcriptomics, and several 3D epigenomic approaches. By analyzing mutants defective for histone H3K27 methylation or demethylation, we uncovered the crucial role of this chromatin mark in short- and previously unnoticed long-range chromatin loop formation. We found that a reduction in H3K27me3 levels led to a decrease in the interactions within Polycomb-associated repressive domains. Regions with lower H3K27me3 levels in the H3K27 methyltransferase clf mutant established new interactions with regions marked with H3K9ac, a histone modification associated with active transcription, indicating that a reduction in H3K27me3 levels induces a global reconfiguration of chromatin architecture. Altogether, our results reveal that the 3D genome organization is tightly linked to reversible histone modifications that govern chromatin interactions. Consequently, nuclear organization dynamics shapes the transcriptional reprogramming during plant development and places H3K27me3 as a key feature in the coregulation of distant genes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cold Spring Harbor Laboratory Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
EPIGENETICS
dc.subject
ARABIDOPSIS
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DNA METHYLATION
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HISTONE MODIFICATIONS
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Polycomb-dependent differential chromatin compartmentalization determines gene coregulation in Arabidopsis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-12-13T18:50:54Z
dc.identifier.eissn
1549-5469
dc.journal.volume
31
dc.journal.number
7
dc.journal.pagination
1230-1244
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Huang, Ying. Universite Paris-Saclay;
dc.description.fil
Fil: Sicar, Sanchari. Universite Paris-Saclay;
dc.description.fil
Fil: Ramirez Prado, Juan S.. Universite Paris-Saclay;
dc.description.fil
Fil: Manza Mianza, Deborah. Universite Paris-Saclay;
dc.description.fil
Fil: Antunez Sanchez, Javier. University of Warwick; Reino Unido
dc.description.fil
Fil: Brik Chaouche, Rim. Universite Paris-Saclay;
dc.description.fil
Fil: Rodriguez Granados, Natalia Y.. Universite Paris-Saclay;
dc.description.fil
Fil: An, Jing. Universite Paris-Saclay;
dc.description.fil
Fil: Bergounioux, Catherine. Universite Paris-Saclay;
dc.description.fil
Fil: Mahfouz, Magdy M.. King Abdullah University of Science and Technology; Arabia Saudita
dc.description.fil
Fil: Hirt, Heribert. Universite Paris-Saclay; . King Abdullah University of Science and Technology; Arabia Saudita
dc.description.fil
Fil: Crespi, Martin. Universite Paris-Saclay;
dc.description.fil
Fil: Concia, Lorenzo. Universite Paris-Saclay; . Ecole Normale Supérieure; Francia
dc.description.fil
Fil: Barneche, Fredy. Ecole Normale Supérieure; Francia
dc.description.fil
Fil: Amiard, Simon. Université Clermont Auvergne; Francia
dc.description.fil
Fil: Probst, Aline V.. Université Clermont Auvergne; Francia
dc.description.fil
Fil: Gutierrez Marcos, Jose. University of Warwick; Reino Unido
dc.description.fil
Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Raynaud, Cécile. Universite Paris-Saclay;
dc.description.fil
Fil: Latrasse, David. Universite Paris-Saclay;
dc.description.fil
Fil: Benhamed, Moussa. Universite Paris-Saclay; . Universite de Paris; Francia. Universite de la Mediterranee. Institut Universitaire de France; Francia
dc.journal.title
Genome Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1101/gr.273771.120
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://genome.cshlp.org/content/31/7/1230
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