Artículo

Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells

Vitale, Alejandra MarielIcon ; Abramovich, Dalhia NuritIcon ; Peluffo, Marina CinthiaIcon ; Meresman, Gabriela FabianaIcon ; Tesone, MartaIcon
Fecha de publicación: 04/2006
Editorial: Elsevier
Revista: Fertility And Sterility
ISSN: 0015-0282
e-ISSN: 1556-5653
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA synthesis on basal conditions. Leuprolide acetate produced an increase in the percentage of apoptotic cells, and when these two factors were co-incubated, ANT blocked the apoptotic effect produced by LA.
Palabras clave: Gnrh-Analogues , Granulosa Cells , Apoptosis , Cell Proliferation
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/18517
URL: http://www.sciencedirect.com/science/article/pii/S0015028206001646
DOI: http://dx.doi.org/ 10.1016/j.fertnstert.2005.09.061
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Vitale, Alejandra Mariel; Abramovich, Dalhia Nurit; Peluffo, Marina Cinthia; Meresman, Gabriela Fabiana; Tesone, Marta; Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells; Elsevier; Fertility And Sterility; 85; 4; 4-2006; 1064-1067
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