Artículo
Autocrine/paracrine involvement of insulin-like growth factor-I and its receptor in chronic lymphocytic leukaemia
Schillaci, Roxana
; Galeano, Adriana; Becu, Damasia
; Spinelli, Olga; Sapia, Sandra; Bezares, Raimundo F.


Fecha de publicación:
07/2005
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
British Journal Of Haematology
ISSN:
0007-1048
e-ISSN:
1365-2141
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Chronic lymphocytic leukaemia (CLL) is characterized by the accumulation of long-lived B lymphocytes blocked in G(0/1) by impaired apoptosis. As insulin-like growth factor-I (IGF-I) is known for its antiapoptotic effects in different cell types, we investigated whether IGF-I and its receptor (IGF-IR) participate in autocrine/paracrine loops affecting the survival of CLL cells. IGF-IR protein and mRNA was present in CLL cells in 44% and 59% of patients respectively. IGF-IR expression in CLL patients was positively correlated with the expression of the antiapoptotic protein Bcl-2 and was involved in CLL cell survival in vitro. Serum IGF-I was elevated in CLL patients, but growth hormone (GH) was normal. CLL cells expressed IGF-I mRNA and secreted the growth factor in vitro. Therefore, local production of IGF-I can account for the increased levels of serum IGF-I, independently of GH, and may be related to autocrine/paracrine control of lymphocyte survival acting at IGF-IR. This is the first demonstration of IGF-IR expression in a subgroup of CLL patients and of its antiapoptotic effects in vitro, highlighting the importance of this growth factor receptor as a possible therapeutic target in CLL.
Palabras clave:
Aged
,
Leukemia
,
Human
,
Growth Hormone
,
Paracrine Communication
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Schillaci, Roxana; Galeano, Adriana; Becu, Damasia; Spinelli, Olga; Sapia, Sandra; et al.; Autocrine/paracrine involvement of insulin-like growth factor-I and its receptor in chronic lymphocytic leukaemia; Wiley Blackwell Publishing, Inc; British Journal Of Haematology; 130; 1; 7-2005; 58–66
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