Artículo
Oxidative stress responses after exposure to triclosan sublethal concentrations: an integrated biomarker approach with a native (Corydoras paleatus) and a model fish species (Danio rerio)
Sager, Emanuel Alejandro
; Scarcia, Paola Inés
; Marino, Damian Jose Gabriel
; Mac Loughlin, Tomas Mariano
; Rossi, Andrea Silvana
; de la Torre, Fernando Roman
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Fecha de publicación:
12/2021
Editorial:
Taylor & Francis
Revista:
Journal of Toxicology and Environmental Health-Part A-Current Issues
ISSN:
1528-7394
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Triclosan (TCS) is a synthetic broad-spectrum antimicrobial agent commonly used world-wide in a range of personal care and sanitizing products detected frequently in aquatic ecosystems. The aim of this study was to examine biochemical markers responses triggered by TCS in Danio rerio and in a native South American fish species (Corydoras paleatus). Further, an integrated approach comparing both test fish species was undertaken. These fish organisms were exposed to 100 or 189 µg TCS/L for 48 h. The activities of catalase (CAT), glutathione-s-transferase (GST), superoxide dismutase (SOD), and lipid peroxidation levels (LPO) and total antioxidant capacity against peroxyl radicals (ACAP) were determined in liver, gills, and brain. Acetylcholinesterase activity (AChE) was measured in the brain. Multivariate analysis showed that the most sensitive hepatic parameters were activities of GST and SOD for C. paleatus while LPO levels were for D. rerio. In gills the same parameters were responsive for C. paleatus but CAT in D. rerio. ACAP and GST activity were responsive parameters in brain of both species. Integrated biomarker responses (IBR) index demonstrated similar trends in both species suggesting this parameter might serve as a useful tool for quantification of integrated responses induced by TCS.
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Articulos(INALI)
Articulos de INST.NAC.DE LIMNOLOGIA (I)
Articulos de INST.NAC.DE LIMNOLOGIA (I)
Articulos(INEDES)
Articulos de INSTITUTO DE ECOLOGIA Y DESARROLLO SUSTENTABLE
Articulos de INSTITUTO DE ECOLOGIA Y DESARROLLO SUSTENTABLE
Citación
Sager, Emanuel Alejandro; Scarcia, Paola Inés; Marino, Damian Jose Gabriel; Mac Loughlin, Tomas Mariano; Rossi, Andrea Silvana; et al.; Oxidative stress responses after exposure to triclosan sublethal concentrations: an integrated biomarker approach with a native (Corydoras paleatus) and a model fish species (Danio rerio); Taylor & Francis; Journal of Toxicology and Environmental Health-Part A-Current Issues; 85; 7; 12-2021; 291-306
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