Mostrar el registro sencillo del ítem
dc.contributor.author
Lorenc, Valeria Erika
dc.contributor.author
Lima e Silva, Raquel
dc.contributor.author
Hackett, Sean F.
dc.contributor.author
Fortmann, Seth D.
dc.contributor.author
Liu, Yuanyuan
dc.contributor.author
Campochiaro, Peter A.
dc.date.available
2023-01-19T18:16:01Z
dc.date.issued
2020-02
dc.identifier.citation
Lorenc, Valeria Erika; Lima e Silva, Raquel; Hackett, Sean F.; Fortmann, Seth D.; Liu, Yuanyuan; et al.; Hepatocyte growth factor is upregulated in ischemic retina and contributes to retinal vascular leakage and neovascularization; Blackwell Publishing; FASEB BioAdvances; 2; 4; 2-2020; 219-233
dc.identifier.issn
2573-9832
dc.identifier.uri
http://hdl.handle.net/11336/185062
dc.description.abstract
In patients with macular edema due to ischemic retinopathy, aqueous levels of hepatocyte growth factor (HGF) correlate with edema severity. We tested whether HGF expression and activity in mice with oxygen-induced ischemic retinopathy supports a role in macular edema. In ischemic retina, HGF was increased in endogenous cells and macrophages associated with retinal neovascularization (NV). HGF activator was increased in and around retinal vessels potentially providing vascular targeting. One day after intravitreous injection of HGF, VE-cadherin was reduced and albumin levels in retina and vitreous were significantly increased indicating vascular leakage. Injection of VEGF caused higher levels of vitreous albumin than HGF, and co-injection of both growth factors caused significantly higher levels than either alone. HGF increased the number of macrophages on the retinal surface, which was blocked by anti-c-Met and abrogated in chemokine (C-C motif) ligand 2 (CCL2)−/− mice. Injection of anti-c-Met significantly decreased leakage within 24 hours and after 5 days it reduced retinal NV in mice with ischemic retinopathy, but had no effect on choroidal NV. These data indicate that HGF is a pro-permeability, pro-inflammatory, and pro-angiogenic factor and along with its activator is increased in ischemic retina providing support for a potential role of HGF in macular edema in ischemic retinopathies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Blackwell Publishing
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
DIABETIC MACULAR EDEMA
dc.subject
HEPATOCYTE GROWTH FACTOR ACTIVATOR
dc.subject
RETINAL VEIN OCCLUSION
dc.subject
VASCULAR LEAKAGE
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Hepatocyte growth factor is upregulated in ischemic retina and contributes to retinal vascular leakage and neovascularization
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T15:23:04Z
dc.journal.volume
2
dc.journal.number
4
dc.journal.pagination
219-233
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva Jersey
dc.description.fil
Fil: Lorenc, Valeria Erika. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Lima e Silva, Raquel. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Hackett, Sean F.. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Fortmann, Seth D.. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Liu, Yuanyuan. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Campochiaro, Peter A.. University Johns Hopkins; Estados Unidos
dc.journal.title
FASEB BioAdvances
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1096/fba.2019-00074
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1096/fba.2019-00074
Archivos asociados