Artículo
3D printed poly(hydroxybutyrate-co-hydroxyvalerate)—45S5 bioactive glass composite resorbable scaffolds suitable for bone regeneration
Araoz, Beatriz
; Karakaya, Emine; González Sánchez Wusener, Ana Elena
; Detsch, Rainer; Bizzotto, Juan Antonio
; Gueron, Geraldine
; Boccaccini, Aldo R.; Hermida, Elida Beatriz
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Fecha de publicación:
06/2021
Editorial:
Springer
Revista:
Journal Of Materials Research
ISSN:
0884-2914
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Abstract: 3D printing for tissue engineering requires biomaterials with mechanical and biological properties suitable for both tissue regeneration and the printing process. A filament made of poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) combined with 45S5 Bioglass (BG) was used to print 3D scaffolds by fused deposition modeling (FDM). Chemical treatment of BG particles with chlorotrimethylsilane (CTMS) improved the ductility of the extruded filaments and allowed excellent printability. Controlling the printing parameter infill density (I%), from 20 to 90%, scaffolds were obtained with interconnected pores and channel sizes in the 100–800 µm range and exhibiting tensile modulus from 0.25 to 1.36 GPa. PHBV + BG scaffolds and PHBV scaffolds coated with CTMS treated BG particles, as a model of a rough and biologically active coating, showed no cytotoxic effects, and cells preferred the scaffolds containing BG in terms of cell spreading. Mechanical and biological properties of the scaffolds were similar to those of the extracellular matrix (ECM) of trabecular bone. Graphic abstract: [Figure not available: see fulltext.]
Palabras clave:
3D PRINTING
,
ADDITIVE MANUFACTURING
,
BIOMEDICAL
,
BONE
,
GLASS
,
POLYMER
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Licencia
Identificadores
Colecciones
Articulos (IIBIO)
Articulos de INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS
Articulos(OCA PQUE. CENTENARIO)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA PQUE. CENTENARIO
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA PQUE. CENTENARIO
Citación
Araoz, Beatriz; Karakaya, Emine; González Sánchez Wusener, Ana Elena; Detsch, Rainer; Bizzotto, Juan Antonio; et al.; 3D printed poly(hydroxybutyrate-co-hydroxyvalerate)—45S5 bioactive glass composite resorbable scaffolds suitable for bone regeneration; Springer; Journal Of Materials Research; 36; 19; 6-2021; 4000-4012
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