Artículo
Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention
Alvarez, Gisela Solange
; Hélary, Christophe; Mebert, Andrea Mathilde
; Wang, Xiaolin; Coradin, Thibaud; Desimone, Martín Federico
Fecha de publicación:
07/2014
Editorial:
Royal Society of Chemistry
Revista:
Journal of Materials Chemistry B
ISSN:
2050-750X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Silica–collagen type I nanocomposite hydrogels are evaluated as medicated dressings to prevent infection in chronic wounds. Two antibiotics, gentamicin and rifamycin, are encapsulated in a single step within plain silica nanoparticles. Their antimicrobial efficiency against Pseudomonas aeruginosa and Staphylococcus aureus is assessed. Gentamycin-loaded 500 nm particles can be immobilized at high silica dose in concentrated collagen hydrogels without modifying their fibrillar structure or impacting on their rheological behavior and increases their proteolytic stability. Gentamicin release from the nanocomposites is sustained over 7 days, offering an unparalleled prolonged antibacterial activity. Particle immobilization also decreases their cytotoxicity towards surface-seeded fibroblast cells. Rifamycin-loaded 100 nm particles significantly alter the collagen hydrogel structure at high silica doses. The thus-obtained nanocomposites show no antibacterial efficiency, due to strong adsorption of rifamycin on collagen fibers. The complex interplay of interactions between drugs, silica and collagen is a key factor regulating the properties of these composite hydrogels as antibiotic-delivering biological dressings and must be taken into account for future extension to other wound healing agents.
Palabras clave:
Antibiotic
,
Silica Nanoparticle
,
Collagen
,
Drug Release
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Identificadores
Colecciones
Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Alvarez, Gisela Solange; Hélary, Christophe; Mebert, Andrea Mathilde; Wang, Xiaolin; Coradin, Thibaud; et al.; Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention; Royal Society of Chemistry; Journal of Materials Chemistry B; 2; 29; 7-2014; 4660-4670
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